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- W3128197876 abstract "Chagas cardiomyopathy is the consequence of a compromised electrical and mechanical cardiac function, with parasite persistence, unbalanced inflammation, and pathological tissue remodelling, being intricately related to myocardial aggression and impaired function. Recent studies have shown that Wnt signaling pathways play a critical role in the pathogenesis of cardiac and vascular diseases. In addition, we have reported that Trypanosoma cruzi infection activates Wnt signaling to promote intracellular replication of the parasites in macrophages, with the treatment of mice with IWP-L6 (an inhibitor of the O-acyl-transferase, PORCN, responsible for the post-translational modifications necessary for Wnt protein secretion) being able to diminish parasitemia and tissue parasitism. Here, we show that inhibition of Wnt signaling during the acute phase of T. cruzi infection controls the parasite replication, inhibits the development of parasite-prone and fibrosis-prone Th2-type immune response, and prevents the development of cardiac abnormalities characteristics of chronic Chagas disease. Our results suggest that the Wnt signaling pathway might be a potential target to prevent the development of T. cruzi-induced cardiomyopathy." @default.
- W3128197876 created "2021-02-15" @default.
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- W3128197876 date "2021-02-12" @default.
- W3128197876 modified "2023-10-10" @default.
- W3128197876 title "Wnt Signaling Plays a Key Role in the Regulation of the Immune Response and Cardiac Damage during <i>Trypanosoma cruzi</i> Infection" @default.
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- W3128197876 cites W1972209585 @default.
- W3128197876 cites W1975476528 @default.
- W3128197876 cites W1978797291 @default.
- W3128197876 cites W1980628314 @default.
- W3128197876 cites W1981775580 @default.
- W3128197876 cites W1982336014 @default.
- W3128197876 cites W1983357763 @default.
- W3128197876 cites W1985916857 @default.
- W3128197876 cites W1987942301 @default.
- W3128197876 cites W1993355276 @default.
- W3128197876 cites W2000587047 @default.
- W3128197876 cites W2006419043 @default.
- W3128197876 cites W2007359758 @default.
- W3128197876 cites W2012380095 @default.
- W3128197876 cites W2013824064 @default.
- W3128197876 cites W2015692913 @default.
- W3128197876 cites W2016586610 @default.
- W3128197876 cites W2027699993 @default.
- W3128197876 cites W2030405016 @default.
- W3128197876 cites W2033001572 @default.
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- W3128197876 cites W2071497196 @default.
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- W3128197876 cites W2081360252 @default.
- W3128197876 cites W2082389210 @default.
- W3128197876 cites W2082653850 @default.
- W3128197876 cites W2087251699 @default.
- W3128197876 cites W2093070846 @default.
- W3128197876 cites W2100142435 @default.
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- W3128197876 cites W2117438992 @default.
- W3128197876 cites W2119787665 @default.
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- W3128197876 cites W2122357566 @default.
- W3128197876 cites W2123471676 @default.
- W3128197876 cites W2128070564 @default.
- W3128197876 cites W2142360968 @default.
- W3128197876 cites W2144219966 @default.
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- W3128197876 cites W2150697906 @default.
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- W3128197876 cites W2165568633 @default.
- W3128197876 cites W2172298170 @default.
- W3128197876 cites W2186241821 @default.
- W3128197876 cites W2272713913 @default.
- W3128197876 cites W2302237864 @default.
- W3128197876 cites W2322471444 @default.
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- W3128197876 cites W2428134552 @default.
- W3128197876 cites W2518236768 @default.
- W3128197876 cites W2583608393 @default.
- W3128197876 cites W2644751370 @default.
- W3128197876 cites W2746229750 @default.
- W3128197876 cites W2768143645 @default.
- W3128197876 cites W2772403987 @default.
- W3128197876 cites W2802305593 @default.
- W3128197876 cites W2884840527 @default.
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- W3128197876 doi "https://doi.org/10.1021/acsinfecdis.0c00590" @default.
- W3128197876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33573383" @default.
- W3128197876 hasPublicationYear "2021" @default.
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