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- W3128199788 abstract "Understanding the association of asthma with severe Coronavirus disease-2019 (COVID-19) is of critical importance to patients and clinicians as the pandemic continues. We performed a matched cohort study using data from the Mass General Brigham Health Care System (Boston, MA). We identified adults (age >18 years) with confirmed COVID-19 and without chronic obstructive pulmonary disease, cystic fibrosis, or interstitial lung disease between March 4, 2020 and July 2, 2020. Asthma was defined as ≥2 asthma diagnosis codes and asthma medication prescription in the one year prior to COVID-19. Up to 5 non-asthma comparators were matched to each asthma patient on age (within 5 years), sex, and date of positive test (within 7 days). Primary outcomes were hospitalization, mechanical ventilation, and death, using multivariable Cox-proportional hazards models accounting for competing risk of death, when appropriate. Patients were followed for these outcomes from diagnosis of COVID-19 until July 2, 2020. Among 562 asthma patients, 199 (21%) were hospitalized, 15 (3%) received mechanical ventilation, and 7 (1%) died. Among 2686 matched comparators, 487 (18%) were hospitalized, 107 (4%) received mechanical ventilation, and 69 (3%) died. The adjusted Hazard Ratios among asthma patients were 0.99 (95% Confidence Interval [CI] 0.80, 1.22) for hospitalization, 0.69 (95%CI 0.36, 1.29) for mechanical ventilation, and 0.30 (95%CI 0.11, 0.80) for death. In this matched cohort study from a large Boston-based healthcare system, asthma was associated with comparable risk of hospitalization and mechanical ventilation and a lower risk of mortality." @default.
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- W3128199788 date "2021-02-01" @default.
- W3128199788 modified "2023-10-11" @default.
- W3128199788 title "COVID-19 severity in asthma patients: A multi-center matched cohort study" @default.
- W3128199788 doi "https://doi.org/10.1016/j.jaci.2020.12.026" @default.
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