FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128205327> ?p ?o ?g. }

• W3128205327 abstract "One of the main problems in the fight against cancer is represented by the immunosuppression it causes. Several research lines have been undertaken to address this issue; one of the most promising is represented by oncolytic viruses. Oncolytic viruses are designed from live attenuated recombinant viruses and are designed to preferentially infect cancer cells, within which they replicate causing their lysis and enhance, through various mechanisms, innate and adaptive immunity. In collaboration with the Etna Biotech company, which was involved in designing five protein constructs composed of five different variants of a monoclonal antibody linked to a viral surface protein, we worked on the modeling and evaluation of these proteins associated with the Measles Virus. The software we used was Swiss-model (https://swissmodel.expasy.org/), a bioinformatics webserver dedicated to homology modeling of 3D protein structures, and Pro-Q (https://proq.bioinfo.se/ProQ/ProQ.html) to perform quality control. We shared our results with the company, which completed laboratory tests for two of the five constructs, confirming our predictions. Transfection experiments are currently underway with two other constructs, while the last one has not yet been subjected to such investigations." @default.
• W3128205327 created "2021-02-15" @default.
• W3128205327 creator A5004880055 @default.
• W3128205327 creator A5044340074 @default.
• W3128205327 creator A5054142948 @default.
• W3128205327 creator A5083311782 @default.
• W3128205327 creator A5086033144 @default.
• W3128205327 date "2020-12-16" @default.
• W3128205327 modified "2023-09-25" @default.
• W3128205327 title "Modeling, simulation and prediction of protein structures for the design of oncolytic viruses" @default.
• W3128205327 cites W1967262248 @default.
• W3128205327 cites W2063512646 @default.
• W3128205327 cites W2065110398 @default.
• W3128205327 cites W2140292630 @default.
• W3128205327 cites W2142678478 @default.
• W3128205327 cites W2152301430 @default.
• W3128205327 cites W2336475824 @default.
• W3128205327 cites W2342152789 @default.
• W3128205327 cites W2494461917 @default.
• W3128205327 cites W2534125264 @default.
• W3128205327 cites W2597399219 @default.
• W3128205327 cites W2804822363 @default.
• W3128205327 cites W2909301717 @default.
• W3128205327 cites W2915318641 @default.
• W3128205327 doi "https://doi.org/10.1109/bibm49941.2020.9313198" @default.
• W3128205327 hasPublicationYear "2020" @default.
• W3128205327 type Work @default.
• W3128205327 sameAs 3128205327 @default.
• W3128205327 citedByCount "0" @default.
• W3128205327 crossrefType "proceedings-article" @default.
• W3128205327 hasAuthorship W3128205327A5004880055 @default.
• W3128205327 hasAuthorship W3128205327A5044340074 @default.
• W3128205327 hasAuthorship W3128205327A5054142948 @default.
• W3128205327 hasAuthorship W3128205327A5083311782 @default.
• W3128205327 hasAuthorship W3128205327A5086033144 @default.
• W3128205327 hasConcept C159047783 @default.
• W3128205327 hasConcept C2522874641 @default.
• W3128205327 hasConcept C41008148 @default.
• W3128205327 hasConcept C49744831 @default.
• W3128205327 hasConcept C70721500 @default.
• W3128205327 hasConcept C82210918 @default.
• W3128205327 hasConcept C86803240 @default.
• W3128205327 hasConceptScore W3128205327C159047783 @default.
• W3128205327 hasConceptScore W3128205327C2522874641 @default.
• W3128205327 hasConceptScore W3128205327C41008148 @default.
• W3128205327 hasConceptScore W3128205327C49744831 @default.
• W3128205327 hasConceptScore W3128205327C70721500 @default.
• W3128205327 hasConceptScore W3128205327C82210918 @default.
• W3128205327 hasConceptScore W3128205327C86803240 @default.
• W3128205327 hasLocation W31282053271 @default.
• W3128205327 hasOpenAccess W3128205327 @default.
• W3128205327 hasPrimaryLocation W31282053271 @default.
• W3128205327 hasRelatedWork W1224117 @default.
• W3128205327 hasRelatedWork W281412 @default.
• W3128205327 hasRelatedWork W3654450 @default.
• W3128205327 hasRelatedWork W4442719 @default.
• W3128205327 hasRelatedWork W5102173 @default.
• W3128205327 hasRelatedWork W5578011 @default.
• W3128205327 hasRelatedWork W5700504 @default.
• W3128205327 hasRelatedWork W571905 @default.
• W3128205327 hasRelatedWork W7357641 @default.
• W3128205327 hasRelatedWork W7746388 @default.
• W3128205327 isParatext "false" @default.
• W3128205327 isRetracted "false" @default.
• W3128205327 magId "3128205327" @default.
• W3128205327 workType "article" @default.