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- W3128211036 abstract "Abstract Epidermal development is a complex process of regulated cellular proliferation, differentiation, and tightly controlled cell death involving multiple cellular signaling networks. Here, we report a first description linking the AAA+ (ATPases associated with various cellular activities) superfamily protein Ruvbl1 to mammalian epidermal development. Keratinocyte-specific Ruvbl1 knockout mice ( Ruvbl1 fl/fl K14:Cre tg ) show a severe phenotype including dramatic structural epidermal defects resulting in the loss of the functional skin barrier and perinatal death. Thus, Ruvbl1 is a newly identified essential player for the development of differentiated epidermis in mice." @default.
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- W3128211036 date "2021-02-12" @default.
- W3128211036 modified "2023-09-23" @default.
- W3128211036 title "Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality" @default.
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- W3128211036 doi "https://doi.org/10.1186/s40348-021-00111-1" @default.
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