Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128220405> ?p ?o ?g. }
- W3128220405 endingPage "104776" @default.
- W3128220405 startingPage "104776" @default.
- W3128220405 abstract "Listeria monocytogenes is a foodborne pathogen that causes systemic infections by crossing the intestinal barrier. However, in vitro analysis of the interaction of L. monocytogenes and small intestinal epithelium has yet to be fully elucidated. To study host responses from intestinal epithelium during L. monocytogenes infection, we used the co-culture model of small intestinal organoids and L. monocytogenes. Results showed that L. monocytogenes mediated damage to intestinal epithelium, especially intestinal stem cells. L. monocytogenes was found to reduce budding rate and increase mortality of organoids. Moreover, it affected the proliferation of epithelial cells and numbers of secretory cells. In addition, it was demonstrated that L. monocytogenes stimulated a reduction in the number of Lgr5+ stem cells. Furthermore, L. monocytogenes affected the expression of Hes1, Math1 and Sox9 to interfere with the differentiation of intestinal stem cells. Collectively, our findings reveal the effects of L. monocytogenes infection on intestinal stem cells and demonstrate that small intestinal organoid is a suitable experimental model for studying intestinal epithelium–pathogen interactions." @default.
- W3128220405 created "2021-02-15" @default.
- W3128220405 creator A5021068534 @default.
- W3128220405 creator A5023369582 @default.
- W3128220405 creator A5069676575 @default.
- W3128220405 creator A5075517974 @default.
- W3128220405 creator A5076220464 @default.
- W3128220405 date "2021-04-01" @default.
- W3128220405 modified "2023-09-27" @default.
- W3128220405 title "Effect of Listeria monocytogenes on intestinal stem cells in the co-culture model of small intestinal organoids" @default.
- W3128220405 cites W1878295921 @default.
- W3128220405 cites W1910721584 @default.
- W3128220405 cites W1936575704 @default.
- W3128220405 cites W1965157206 @default.
- W3128220405 cites W1978518041 @default.
- W3128220405 cites W1982603620 @default.
- W3128220405 cites W1983422325 @default.
- W3128220405 cites W1990066341 @default.
- W3128220405 cites W1990613666 @default.
- W3128220405 cites W1994216131 @default.
- W3128220405 cites W1996629345 @default.
- W3128220405 cites W2001055523 @default.
- W3128220405 cites W2002513358 @default.
- W3128220405 cites W2023816042 @default.
- W3128220405 cites W2024121049 @default.
- W3128220405 cites W2030791386 @default.
- W3128220405 cites W2032782331 @default.
- W3128220405 cites W2042086385 @default.
- W3128220405 cites W2043667001 @default.
- W3128220405 cites W2054013529 @default.
- W3128220405 cites W2069107251 @default.
- W3128220405 cites W2081554080 @default.
- W3128220405 cites W2098482477 @default.
- W3128220405 cites W2098983973 @default.
- W3128220405 cites W2103272211 @default.
- W3128220405 cites W2124566766 @default.
- W3128220405 cites W2129517736 @default.
- W3128220405 cites W2133728642 @default.
- W3128220405 cites W2152501601 @default.
- W3128220405 cites W2155040292 @default.
- W3128220405 cites W2159155233 @default.
- W3128220405 cites W2171560127 @default.
- W3128220405 cites W2201442248 @default.
- W3128220405 cites W2258083311 @default.
- W3128220405 cites W2347061404 @default.
- W3128220405 cites W2402880302 @default.
- W3128220405 cites W2462981999 @default.
- W3128220405 cites W2509314068 @default.
- W3128220405 cites W2519568058 @default.
- W3128220405 cites W2531170519 @default.
- W3128220405 cites W2600741255 @default.
- W3128220405 cites W2770899020 @default.
- W3128220405 cites W2791416031 @default.
- W3128220405 cites W2795260477 @default.
- W3128220405 cites W2806840045 @default.
- W3128220405 cites W2898582815 @default.
- W3128220405 cites W2900263258 @default.
- W3128220405 cites W2909033323 @default.
- W3128220405 cites W2910625890 @default.
- W3128220405 cites W2917423992 @default.
- W3128220405 cites W3012238762 @default.
- W3128220405 doi "https://doi.org/10.1016/j.micpath.2021.104776" @default.
- W3128220405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33548482" @default.
- W3128220405 hasPublicationYear "2021" @default.
- W3128220405 type Work @default.
- W3128220405 sameAs 3128220405 @default.
- W3128220405 citedByCount "10" @default.
- W3128220405 countsByYear W31282204052022 @default.
- W3128220405 countsByYear W31282204052023 @default.
- W3128220405 crossrefType "journal-article" @default.
- W3128220405 hasAuthorship W3128220405A5021068534 @default.
- W3128220405 hasAuthorship W3128220405A5023369582 @default.
- W3128220405 hasAuthorship W3128220405A5069676575 @default.
- W3128220405 hasAuthorship W3128220405A5075517974 @default.
- W3128220405 hasAuthorship W3128220405A5076220464 @default.
- W3128220405 hasConcept C10116572 @default.
- W3128220405 hasConcept C126322002 @default.
- W3128220405 hasConcept C2776460866 @default.
- W3128220405 hasConcept C2781077229 @default.
- W3128220405 hasConcept C2781350384 @default.
- W3128220405 hasConcept C28328180 @default.
- W3128220405 hasConcept C3019368612 @default.
- W3128220405 hasConcept C31695470 @default.
- W3128220405 hasConcept C523546767 @default.
- W3128220405 hasConcept C529295009 @default.
- W3128220405 hasConcept C54355233 @default.
- W3128220405 hasConcept C55427017 @default.
- W3128220405 hasConcept C71924100 @default.
- W3128220405 hasConcept C86803240 @default.
- W3128220405 hasConcept C89423630 @default.
- W3128220405 hasConcept C95444343 @default.
- W3128220405 hasConceptScore W3128220405C10116572 @default.
- W3128220405 hasConceptScore W3128220405C126322002 @default.
- W3128220405 hasConceptScore W3128220405C2776460866 @default.
- W3128220405 hasConceptScore W3128220405C2781077229 @default.
- W3128220405 hasConceptScore W3128220405C2781350384 @default.
- W3128220405 hasConceptScore W3128220405C28328180 @default.
- W3128220405 hasConceptScore W3128220405C3019368612 @default.