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• W3128227568 abstract "ABSTRACT The evolutionarily conserved LIN-2 (CASK)/LIN-7 (Lin7A-C)/LIN-10 (APBA1) complex plays an important role in regulating spatial organization of membrane proteins and signaling components. In Caenorhabditis elegans, the complex is essential for the development of the vulva by promoting the localization of the sole Epidermal growth factor receptor (EGFR) ortholog LET-23 to the basolateral membrane of the vulva precursor cells where it can specify the vulval cell fate. To understand how the LIN-2/7/10 complex regulates receptor localization, we determined its expression and localization during vulva development. We found that LIN-7 colocalizes with LET-23 EGFR at the basolateral membrane, whereas the LIN-2/7/10 complex colocalizes with LET-23 EGFR at cytoplasmic punctae that mostly overlap with the Golgi. Furthermore, LIN-10 recruits LIN-2, which in turn recruits LIN-7. We demonstrate that the complex forms in vivo with a particularly strong interaction and colocalization between LIN-2 and LIN-7, consistent with them forming a subcomplex. Thus, the LIN-2/7/10 complex forms on the Golgi on which it likely targets LET-23 EGFR trafficking to the basolateral membrane rather than functioning as a tether." @default.
• W3128227568 created "2021-02-15" @default.
• W3128227568 creator A5036111224 @default.
• W3128227568 creator A5078092478 @default.
• W3128227568 date "2021-03-01" @default.
• W3128227568 modified "2023-09-27" @default.
• W3128227568 title "Golgi localization of the LIN-2/7/10 complex points to a role in basolateral secretion of LET-23 EGFR in the <i>Caenorhabditis elegans</i> vulval precursor cells" @default.
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• W3128227568 cites W1946787458 @default.
• W3128227568 cites W1966704740 @default.
• W3128227568 cites W1966711413 @default.
• W3128227568 cites W1969166228 @default.
• W3128227568 cites W1969695222 @default.
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• W3128227568 cites W1971783973 @default.
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• W3128227568 doi "https://doi.org/10.1242/dev.194167" @default.
• W3128227568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33526581" @default.
• W3128227568 hasPublicationYear "2021" @default.
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