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- W3128252023 abstract "Essential oils (EOs), which are complex biomolecules composed of volatile compounds, have emerged as a new strategy to deal with bacterial infections and as a valid alternative to synthetic drugs. Here, we report the production and modification of wet-spun microfibers made of cellulose acetate (CA) and polycaprolactone (PCL) with the EOs cinnamon leaf oil (CLO), cajeput oil (CJO), and clove oil (CO). These were selected from a group of 20 EOs according to their minimal inhibitory concentration (MIC) against Staphylococcus aureus (<22.4 mg/mL) and Escherichia coli (<11.2 mg/mL) bacteria. Microfibers were produced by wet-spinning at an extrusion rate of 0.5 mL/h directly into an ethanol coagulation bath. EOs loading was accomplished by immersion in ethanol solutions containing the EOs at 2xMIC. Incorporation was confirmed by UV-Visible spectroscopy and Fourier-transformed infrared spectroscopy. After 72 h of incubation, microfibers contained 14%, 66% and 76% of the MIC values of CLO, CO and CJO, respectively. Unloaded and loaded microfibers were characterized as uniform and homogeneous; no significant differences were detected. EO-modified microfibers were effective against the tested bacteria. Considering the amount immobilized, CLO-containing fibers were deemed the most effective from the group, suggesting a superior affinity of the EOs active groups towards the CA/PCL matrix. These results indicate that CA/PCL microfibers loaded with EOs have potential for biomedical application in which infection control is the target." @default.
- W3128252023 created "2021-02-15" @default.
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- W3128252023 date "2020-11-11" @default.
- W3128252023 modified "2023-09-23" @default.
- W3128252023 title "Activity of Wet-Spun Fibers Chemically Modified with Active Biomolecules against Gram-Positive and Gram-Negative Bacteria" @default.
- W3128252023 doi "https://doi.org/10.3390/iocn2020-07935" @default.
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