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- W3128260236 abstract "The suprachiasmatic nucleus (SCN) in the brain is the master regulator of the circadian clocks throughout the human body. With increasing age the circadian clock in humans and other mammals becomes increasingly disorganized leading to a large number of more or less well-categorized problems. While a lot of aging research has focused on the peripheral clocks in tissues across organisms, it remains a paramount task to quantify aging of the most important master clock, the human SCN. Furthermore, a pipeline needs to be developed with therapies to mitigate the systemic cellular circadian dysfunction in the elderly and ultimately repair and reverse aging of the SCN itself. A disease classification for the aging SCN, Circadian Clock Neuronal Senile Atrophy (CIRCLONSA syndrome), would improve research funding and goal-oriented biotechnological entrepreneurship." @default.
- W3128260236 created "2021-02-15" @default.
- W3128260236 creator A5039243504 @default.
- W3128260236 date "2021-08-01" @default.
- W3128260236 modified "2023-09-25" @default.
- W3128260236 title "Aging of the Suprachiasmatic Nucleus, <i>CIRCLONSA Syndrome</i>, Implications for Regenerative Medicine and Restoration of the Master Body Clock" @default.
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- W3128260236 doi "https://doi.org/10.1089/rej.2020.2388" @default.
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