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- W3128266009 abstract "Abstract As a framework for tissue engineering regeneration, the characteristics of cell scaffold materials directly affect cell adhesion, migration and metabolism. In this study, we have fabricated decellularized and decalcified fish scale-derived scaffolds and determined its basic physicochemical properties to serve as cell scaffolds in tissue engineering. Scanning electron microscopy (SEM) results showed that there were radial grooves and ring ridges on the surface of the scale-derived scaffolds, which could simulate three-dimensional microenvironment for cells culture. Similarity to the bone extracellular matrix, the main components of the fish scales were hydroxyapatite (HA) and type I collagen fibers, which were conducive to cells spreading and proliferation. Moreover, for culturing L929 cells and rat bone marrow mesenchymal stem cells (BMSCs), the fish scales as cell scaffolds exhibited high cytocompatibility to enhance cells adhesion and proliferation, and also displayed the ability to guide cells migration along the ridge channels. Accordingly, the results suggested that the fish scale-derived scaffolds had a great potential as a natural extracellular matrix for tissue engineering." @default.
- W3128266009 created "2021-02-15" @default.
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- W3128266009 date "2021-03-01" @default.
- W3128266009 modified "2023-10-14" @default.
- W3128266009 title "Construction and characterization of degradable fish scales for enhancing cellular adhesion and potential using as tissue engineering scaffolds" @default.
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- W3128266009 doi "https://doi.org/10.1016/j.msec.2021.111919" @default.
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