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- W3128278378 abstract "Cancer cachexia (CC) is a multifactorial syndrome in patients with advanced cancer characterized by weight loss via skeletal-muscle and adipose-tissue atrophy, catabolic activity, and systemic inflammation. CC is correlated with functional impairment, reduced therapeutic responsiveness, and poor prognosis, and is a major cause of death in cancer patients. In colorectal cancer (CRC), cachexia affects around 50–61% of patients, but remains overlooked, understudied, and uncured. The mechanisms driving CC are not fully understood but are related, at least in part, to the local and systemic immune response to the tumor. Accumulating evidence demonstrates a significant role of tumor microenvironment (TME) cells (e.g., macrophages, neutrophils, and fibroblasts) in both cancer progression and tumor-induced cachexia, through the production of multiple procachectic factors. The most important role in CRC-associated cachexia is played by pro-inflammatory cytokines, including the tumor necrosis factor α (TNFα), originally known as cachectin, Interleukin (IL)-1, IL-6, and certain chemokines (e.g., IL-8). Heterogeneous CRC cells themselves also produce numerous cytokines (including chemokines), as well as novel factors called “cachexokines”. The tumor microenvironment (TME) contributes to systemic inflammation and increased oxidative stress and fibrosis. This review summarizes the current knowledge on the role of TME cellular components in CRC-associated cachexia, as well as discusses the potential role of selected mediators secreted by colorectal cancer cells in cooperation with tumor-associated immune and non-immune cells of tumor microenvironment in inducing or potentiating cancer cachexia. This knowledge serves to aid the understanding of the mechanisms of this process, as well as prevent its consequences." @default.
- W3128278378 created "2021-02-15" @default.
- W3128278378 creator A5043651581 @default.
- W3128278378 date "2021-02-04" @default.
- W3128278378 modified "2023-10-02" @default.
- W3128278378 title "The Role of Tumor Microenvironment Cells in Colorectal Cancer (CRC) Cachexia" @default.
- W3128278378 cites W1482991603 @default.
- W3128278378 cites W1575907125 @default.
- W3128278378 cites W1831388254 @default.
- W3128278378 cites W1858023513 @default.
- W3128278378 cites W1937406958 @default.
- W3128278378 cites W1958854122 @default.
- W3128278378 cites W1963931856 @default.
- W3128278378 cites W1971627258 @default.
- W3128278378 cites W1980029123 @default.
- W3128278378 cites W1983064902 @default.
- W3128278378 cites W1983660080 @default.
- W3128278378 cites W1984103507 @default.
- W3128278378 cites W1985124617 @default.
- W3128278378 cites W1988539555 @default.
- W3128278378 cites W1991225025 @default.
- W3128278378 cites W1991697424 @default.
- W3128278378 cites W1992511639 @default.
- W3128278378 cites W1997011364 @default.
- W3128278378 cites W1999713673 @default.
- W3128278378 cites W200085739 @default.
- W3128278378 cites W2001089941 @default.
- W3128278378 cites W2002209097 @default.
- W3128278378 cites W2008561463 @default.
- W3128278378 cites W2009062406 @default.
- W3128278378 cites W2021354449 @default.
- W3128278378 cites W2024876996 @default.
- W3128278378 cites W2030342430 @default.
- W3128278378 cites W2030772730 @default.
- W3128278378 cites W2030797581 @default.
- W3128278378 cites W2031411519 @default.
- W3128278378 cites W2033917892 @default.
- W3128278378 cites W2034127653 @default.
- W3128278378 cites W2035824594 @default.
- W3128278378 cites W2037102067 @default.
- W3128278378 cites W2037900813 @default.
- W3128278378 cites W2041399091 @default.
- W3128278378 cites W2043772361 @default.
- W3128278378 cites W2046491600 @default.
- W3128278378 cites W2050763541 @default.
- W3128278378 cites W2051804282 @default.
- W3128278378 cites W2054253617 @default.
- W3128278378 cites W2057436385 @default.
- W3128278378 cites W2060934232 @default.
- W3128278378 cites W2067623537 @default.
- W3128278378 cites W2070312924 @default.
- W3128278378 cites W2079073527 @default.
- W3128278378 cites W2079613095 @default.
- W3128278378 cites W2080692874 @default.
- W3128278378 cites W2081277484 @default.
- W3128278378 cites W2084707952 @default.
- W3128278378 cites W2086046027 @default.
- W3128278378 cites W2086920509 @default.
- W3128278378 cites W2090008386 @default.
- W3128278378 cites W2094067573 @default.
- W3128278378 cites W2094747667 @default.
- W3128278378 cites W2094762415 @default.
- W3128278378 cites W2107251975 @default.
- W3128278378 cites W2109424201 @default.
- W3128278378 cites W2110736689 @default.
- W3128278378 cites W2114717530 @default.
- W3128278378 cites W2116407404 @default.
- W3128278378 cites W2125253058 @default.
- W3128278378 cites W2126592589 @default.
- W3128278378 cites W2127985894 @default.
- W3128278378 cites W2130053803 @default.
- W3128278378 cites W2130902091 @default.
- W3128278378 cites W2137590405 @default.
- W3128278378 cites W2138217484 @default.
- W3128278378 cites W2145280166 @default.
- W3128278378 cites W2148901052 @default.
- W3128278378 cites W2150215918 @default.
- W3128278378 cites W2157975860 @default.
- W3128278378 cites W2161499267 @default.
- W3128278378 cites W2166106808 @default.
- W3128278378 cites W2172020799 @default.
- W3128278378 cites W2181967807 @default.
- W3128278378 cites W2218743444 @default.
- W3128278378 cites W2228596173 @default.
- W3128278378 cites W2268856907 @default.
- W3128278378 cites W2281478760 @default.
- W3128278378 cites W2287603172 @default.
- W3128278378 cites W2300321017 @default.
- W3128278378 cites W2301680230 @default.
- W3128278378 cites W2331843840 @default.
- W3128278378 cites W2344423928 @default.
- W3128278378 cites W2345985540 @default.
- W3128278378 cites W2415649514 @default.
- W3128278378 cites W2463253051 @default.
- W3128278378 cites W2467291053 @default.
- W3128278378 cites W2512899508 @default.
- W3128278378 cites W2536406870 @default.
- W3128278378 cites W2557277725 @default.