FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128293882> ?p ?o ?g. }

• W3128293882 endingPage "203663" @default.
• W3128293882 startingPage "203663" @default.
• W3128293882 abstract "Asb2, ankyrin repeat, and SOCS box protein 2 form an E3 ubiquitin ligase complex. Asb2 ubiquitin ligase activity drives the degradation of filamins, which have essential functions in humans. The placenta is a temporary organ that forms during pregnancy, and normal placentation is important for survival and growth of the fetus. Recent studies have shown that approximately 25-30% of knockout (KO) mice have non-viable offspring, and 68% of knockout lines exhibit placental dysmorphologies. There are very few studies on Asb2, with insufficient research on its role in placental development. Therefore, we generated Asb2 knockout mice and undertook to investigate Asb2 expression during organogenesis, and to identify its role in early embryonic and placental development. The external morphology of KO embryos revealed abnormal phenotypes including growth retardation, pericardial effusion, pale color, and especially heart beat defect from E 9.5. Furthermore, Asb2 expression was observed in the heart from E 9.5, indicating that it is specifically expressed during early heart formation, resulting in embryonic lethality. Histological analysis of E 10.5 KO heart showed malformations such as failure of chamber formation, reduction in trabeculated myocardium length, absence of mesenchymal cells, and destruction of myocardium wall. Moreover, the histological results of Asb2-deficient placenta showed abnormal phenotypes including small labyrinth and reduced vascular complexity, indicating that failure to establish mature circulatory pattern affects the embryonic development and results in early mortality. Collectively, our results demonstrate that Asb2 knockout mice have placental defects, that subsequently result in failure to form a normal cardiac septum, and thereby result in embryo mortality in utero at around E 9.5." @default.
• W3128293882 created "2021-02-15" @default.
• W3128293882 creator A5004913620 @default.
• W3128293882 creator A5009346211 @default.
• W3128293882 creator A5036359331 @default.
• W3128293882 creator A5053636101 @default.
• W3128293882 creator A5079770275 @default.
• W3128293882 creator A5080075266 @default.
• W3128293882 creator A5088152116 @default.
• W3128293882 date "2021-03-01" @default.
• W3128293882 modified "2023-09-28" @default.
• W3128293882 title "Heart defects and embryonic lethality in Asb2 knock out mice correlate with placental defects" @default.
• W3128293882 cites W1832030339 @default.
• W3128293882 cites W1968703258 @default.
• W3128293882 cites W1969772038 @default.
• W3128293882 cites W1970508192 @default.
• W3128293882 cites W1987399378 @default.
• W3128293882 cites W1993235298 @default.
• W3128293882 cites W2001848617 @default.
• W3128293882 cites W2007006841 @default.
• W3128293882 cites W2007102240 @default.
• W3128293882 cites W2020054949 @default.
• W3128293882 cites W2024188740 @default.
• W3128293882 cites W2024189377 @default.
• W3128293882 cites W2039684521 @default.
• W3128293882 cites W2042781130 @default.
• W3128293882 cites W2052735334 @default.
• W3128293882 cites W2059324975 @default.
• W3128293882 cites W2064212960 @default.
• W3128293882 cites W2078794317 @default.
• W3128293882 cites W2082390264 @default.
• W3128293882 cites W2085544097 @default.
• W3128293882 cites W2090453278 @default.
• W3128293882 cites W2091564445 @default.
• W3128293882 cites W2102783132 @default.
• W3128293882 cites W2109014212 @default.
• W3128293882 cites W2126591019 @default.
• W3128293882 cites W2140158862 @default.
• W3128293882 cites W2333123700 @default.
• W3128293882 cites W2789302016 @default.
• W3128293882 cites W2789857900 @default.
• W3128293882 cites W3009279595 @default.
• W3128293882 cites W4230866226 @default.
• W3128293882 doi "https://doi.org/10.1016/j.cdev.2021.203663" @default.
• W3128293882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33993984" @default.
• W3128293882 hasPublicationYear "2021" @default.
• W3128293882 type Work @default.
• W3128293882 sameAs 3128293882 @default.
• W3128293882 citedByCount "1" @default.
• W3128293882 countsByYear W31282938822022 @default.
• W3128293882 crossrefType "journal-article" @default.
• W3128293882 hasAuthorship W3128293882A5004913620 @default.
• W3128293882 hasAuthorship W3128293882A5009346211 @default.
• W3128293882 hasAuthorship W3128293882A5036359331 @default.
• W3128293882 hasAuthorship W3128293882A5053636101 @default.
• W3128293882 hasAuthorship W3128293882A5079770275 @default.
• W3128293882 hasAuthorship W3128293882A5080075266 @default.
• W3128293882 hasAuthorship W3128293882A5088152116 @default.
• W3128293882 hasBestOaLocation W31282938821 @default.
• W3128293882 hasConcept C104317684 @default.
• W3128293882 hasConcept C127716648 @default.
• W3128293882 hasConcept C134459356 @default.
• W3128293882 hasConcept C145103041 @default.
• W3128293882 hasConcept C164659718 @default.
• W3128293882 hasConcept C16685009 @default.
• W3128293882 hasConcept C172680121 @default.
• W3128293882 hasConcept C182704531 @default.
• W3128293882 hasConcept C196843134 @default.
• W3128293882 hasConcept C203014093 @default.
• W3128293882 hasConcept C25602115 @default.
• W3128293882 hasConcept C2776953305 @default.
• W3128293882 hasConcept C2777837822 @default.
• W3128293882 hasConcept C2779234561 @default.
• W3128293882 hasConcept C45167389 @default.
• W3128293882 hasConcept C54355233 @default.
• W3128293882 hasConcept C71924100 @default.
• W3128293882 hasConcept C86803240 @default.
• W3128293882 hasConcept C87073359 @default.
• W3128293882 hasConcept C95444343 @default.
• W3128293882 hasConceptScore W3128293882C104317684 @default.
• W3128293882 hasConceptScore W3128293882C127716648 @default.
• W3128293882 hasConceptScore W3128293882C134459356 @default.
• W3128293882 hasConceptScore W3128293882C145103041 @default.
• W3128293882 hasConceptScore W3128293882C164659718 @default.
• W3128293882 hasConceptScore W3128293882C16685009 @default.
• W3128293882 hasConceptScore W3128293882C172680121 @default.
• W3128293882 hasConceptScore W3128293882C182704531 @default.
• W3128293882 hasConceptScore W3128293882C196843134 @default.
• W3128293882 hasConceptScore W3128293882C203014093 @default.
• W3128293882 hasConceptScore W3128293882C25602115 @default.
• W3128293882 hasConceptScore W3128293882C2776953305 @default.
• W3128293882 hasConceptScore W3128293882C2777837822 @default.
• W3128293882 hasConceptScore W3128293882C2779234561 @default.
• W3128293882 hasConceptScore W3128293882C45167389 @default.
• W3128293882 hasConceptScore W3128293882C54355233 @default.
• W3128293882 hasConceptScore W3128293882C71924100 @default.
• W3128293882 hasConceptScore W3128293882C86803240 @default.
• W3128293882 hasConceptScore W3128293882C87073359 @default.

• next