FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128308904> ?p ?o ?g. }

• W3128308904 abstract "Abstract From the earliest days of using natural remedies to modern applications of clinically tested medications, combining therapies for disease treatment has been standard practice. Combination treatments can exhibit synergistic effects, broadly defined as a greater-than-additive effect of two or more therapeutic agents. Indeed, clinicians often use their experience and expertise to tailor such combinations in the hopes of maximizing the therapeutic effect. Alongside these efforts, computational studies into understanding and predicting the biophysical underpinnings of how synergy is achieved have benefitted from high-throughput screening and computational biology. One challenge is how to best design and analyze the results of synergy studies performed at scale, especially because the number of possible combinations to test quickly becomes unmanageable, and the tools to analyze the resulting data are quite new. Nevertheless, the benefits of such studies are clear — by combining multiple drugs in the treatment of infectious disease and cancer, for instance, one can lessen host toxicity and simultaneously reduce the likelihood of resistance to treatment. In this study, we extend the widely validated chemogenomic HIPHOP assay to drug combinations. We identify a class of “combination-specific sensitive strains” that suggest mechanisms for the synergies we observe and further suggest focused follow-up studies." @default.
• W3128308904 created "2021-02-15" @default.
• W3128308904 creator A5019974346 @default.
• W3128308904 creator A5027866777 @default.
• W3128308904 creator A5040783905 @default.
• W3128308904 creator A5048868904 @default.
• W3128308904 creator A5069396293 @default.
• W3128308904 date "2021-02-02" @default.
• W3128308904 modified "2023-09-26" @default.
• W3128308904 title "Combining chemogenomic and gene-dose assays to investigate drug synergy" @default.
• W3128308904 cites W1507194301 @default.
• W3128308904 cites W1592483428 @default.
• W3128308904 cites W1970250905 @default.
• W3128308904 cites W1975728616 @default.
• W3128308904 cites W1981784972 @default.
• W3128308904 cites W1983265239 @default.
• W3128308904 cites W1984653721 @default.
• W3128308904 cites W1996000832 @default.
• W3128308904 cites W2006222270 @default.
• W3128308904 cites W2012970082 @default.
• W3128308904 cites W2016836376 @default.
• W3128308904 cites W2019165625 @default.
• W3128308904 cites W2023518810 @default.
• W3128308904 cites W2026149168 @default.
• W3128308904 cites W2031410708 @default.
• W3128308904 cites W2031932867 @default.
• W3128308904 cites W2040739348 @default.
• W3128308904 cites W2046207683 @default.
• W3128308904 cites W2060481943 @default.
• W3128308904 cites W2060737851 @default.
• W3128308904 cites W2063013559 @default.
• W3128308904 cites W2064825877 @default.
• W3128308904 cites W2065359944 @default.
• W3128308904 cites W2076579091 @default.
• W3128308904 cites W2098824895 @default.
• W3128308904 cites W2113985797 @default.
• W3128308904 cites W2114859236 @default.
• W3128308904 cites W2117164965 @default.
• W3128308904 cites W2120034951 @default.
• W3128308904 cites W2130410032 @default.
• W3128308904 cites W2133102806 @default.
• W3128308904 cites W2140595402 @default.
• W3128308904 cites W2145068784 @default.
• W3128308904 cites W2153134824 @default.
• W3128308904 cites W2155626151 @default.
• W3128308904 cites W2169388870 @default.
• W3128308904 cites W2271163371 @default.
• W3128308904 cites W2394996744 @default.
• W3128308904 cites W2474522617 @default.
• W3128308904 cites W2612278270 @default.
• W3128308904 cites W2613803582 @default.
• W3128308904 cites W2753638618 @default.
• W3128308904 cites W2788593837 @default.
• W3128308904 cites W2803006006 @default.
• W3128308904 cites W2919925869 @default.
• W3128308904 cites W2998814107 @default.
• W3128308904 cites W3016698209 @default.
• W3128308904 cites W3048825106 @default.
• W3128308904 cites W3099535328 @default.
• W3128308904 doi "https://doi.org/10.1101/2021.02.01.429253" @default.
• W3128308904 hasPublicationYear "2021" @default.
• W3128308904 type Work @default.
• W3128308904 sameAs 3128308904 @default.
• W3128308904 citedByCount "0" @default.
• W3128308904 crossrefType "posted-content" @default.
• W3128308904 hasAuthorship W3128308904A5019974346 @default.
• W3128308904 hasAuthorship W3128308904A5027866777 @default.
• W3128308904 hasAuthorship W3128308904A5040783905 @default.
• W3128308904 hasAuthorship W3128308904A5048868904 @default.
• W3128308904 hasAuthorship W3128308904A5069396293 @default.
• W3128308904 hasBestOaLocation W31283089041 @default.
• W3128308904 hasConcept C112930515 @default.
• W3128308904 hasConcept C142724271 @default.
• W3128308904 hasConcept C2779134260 @default.
• W3128308904 hasConcept C2780035454 @default.
• W3128308904 hasConcept C41008148 @default.
• W3128308904 hasConcept C70721500 @default.
• W3128308904 hasConcept C71924100 @default.
• W3128308904 hasConcept C86803240 @default.
• W3128308904 hasConcept C98274493 @default.
• W3128308904 hasConceptScore W3128308904C112930515 @default.
• W3128308904 hasConceptScore W3128308904C142724271 @default.
• W3128308904 hasConceptScore W3128308904C2779134260 @default.
• W3128308904 hasConceptScore W3128308904C2780035454 @default.
• W3128308904 hasConceptScore W3128308904C41008148 @default.
• W3128308904 hasConceptScore W3128308904C70721500 @default.
• W3128308904 hasConceptScore W3128308904C71924100 @default.
• W3128308904 hasConceptScore W3128308904C86803240 @default.
• W3128308904 hasConceptScore W3128308904C98274493 @default.
• W3128308904 hasLocation W31283089041 @default.
• W3128308904 hasOpenAccess W3128308904 @default.
• W3128308904 hasPrimaryLocation W31283089041 @default.
• W3128308904 hasRelatedWork W1983544050 @default.
• W3128308904 hasRelatedWork W2082482010 @default.
• W3128308904 hasRelatedWork W2125138090 @default.
• W3128308904 hasRelatedWork W2377626647 @default.
• W3128308904 hasRelatedWork W2426261983 @default.
• W3128308904 hasRelatedWork W2748952813 @default.
• W3128308904 hasRelatedWork W2765379856 @default.
• W3128308904 hasRelatedWork W2794783788 @default.

• next