Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128333191> ?p ?o ?g. }
- W3128333191 endingPage "100" @default.
- W3128333191 startingPage "100" @default.
- W3128333191 abstract "Background: A good survival rate among patients with beta thalassemia major (beta-TM) has led to the appearance of an unrecognized renal disease. Therefore, we aimed to assess the role of serum cystatin-C as a promising marker for the detection of renal glomerular dysfunction and N-acetyl beta-D-glucosaminidase (NAG) and kidney injury molecule 1 (KIM-1) as potential markers for the detection of renal tubular injury in beta-TM children. Methods: This case-control study was implemented on 100 beta-TM children receiving regular blood transfusions and undergoing iron chelation therapy and 100 healthy children as a control group. Detailed histories of complete physical and clinical examinations were recorded. All subjected children underwent blood and urinary investigations. Results: There was a significant increase in serum cystatin-C (p < 0.001) and a significant decrease in eGFR in patients with beta-TM compared with controls (p = 0.01). There was a significant increase in urinary NAG, KIM-1, UNAG/Cr, and UKIM-1/Cr (p < 0.001) among thalassemic children, with a significant positive correlation between serum cystatin-C, NAG and KIM-1 as regards serum ferritin, creatinine, and urea among thalassemic patients. A negative correlation between serum cystatin-C and urinary markers with eGFR was noted. Conclusion: Serum cystatin-C is a good marker for detection of glomerular dysfunction. NAG and KIM-1 may have a predictive role in the detection of kidney injury in beta-TM children." @default.
- W3128333191 created "2021-02-15" @default.
- W3128333191 creator A5007515910 @default.
- W3128333191 creator A5026841275 @default.
- W3128333191 creator A5057964730 @default.
- W3128333191 creator A5074768497 @default.
- W3128333191 creator A5076668383 @default.
- W3128333191 creator A5076729993 @default.
- W3128333191 creator A5082563570 @default.
- W3128333191 date "2021-02-03" @default.
- W3128333191 modified "2023-10-06" @default.
- W3128333191 title "Assessment of Subclinical Renal Glomerular and Tubular Dysfunction in Children with Beta Thalassemia Major" @default.
- W3128333191 cites W1536143313 @default.
- W3128333191 cites W1549746240 @default.
- W3128333191 cites W1812197425 @default.
- W3128333191 cites W1964227262 @default.
- W3128333191 cites W1968016546 @default.
- W3128333191 cites W1993384837 @default.
- W3128333191 cites W1999094142 @default.
- W3128333191 cites W2013316106 @default.
- W3128333191 cites W2018173221 @default.
- W3128333191 cites W2049219774 @default.
- W3128333191 cites W2057721700 @default.
- W3128333191 cites W2060664419 @default.
- W3128333191 cites W2065582745 @default.
- W3128333191 cites W2069986446 @default.
- W3128333191 cites W2073083848 @default.
- W3128333191 cites W2075757414 @default.
- W3128333191 cites W2083481160 @default.
- W3128333191 cites W2086207383 @default.
- W3128333191 cites W2087655054 @default.
- W3128333191 cites W2091311787 @default.
- W3128333191 cites W2106811759 @default.
- W3128333191 cites W2109355833 @default.
- W3128333191 cites W2122855609 @default.
- W3128333191 cites W2123152382 @default.
- W3128333191 cites W2132381451 @default.
- W3128333191 cites W2145052442 @default.
- W3128333191 cites W2158458517 @default.
- W3128333191 cites W2168905961 @default.
- W3128333191 cites W2170578240 @default.
- W3128333191 cites W2403555441 @default.
- W3128333191 cites W2584905071 @default.
- W3128333191 cites W2610109423 @default.
- W3128333191 cites W2752927670 @default.
- W3128333191 cites W2755336895 @default.
- W3128333191 cites W2797062408 @default.
- W3128333191 cites W2883324756 @default.
- W3128333191 cites W2892241843 @default.
- W3128333191 cites W2903239528 @default.
- W3128333191 cites W2971811007 @default.
- W3128333191 cites W3007130402 @default.
- W3128333191 cites W4211119300 @default.
- W3128333191 doi "https://doi.org/10.3390/children8020100" @default.
- W3128333191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7913373" @default.
- W3128333191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33546213" @default.
- W3128333191 hasPublicationYear "2021" @default.
- W3128333191 type Work @default.
- W3128333191 sameAs 3128333191 @default.
- W3128333191 citedByCount "5" @default.
- W3128333191 countsByYear W31283331912021 @default.
- W3128333191 countsByYear W31283331912022 @default.
- W3128333191 countsByYear W31283331912023 @default.
- W3128333191 crossrefType "journal-article" @default.
- W3128333191 hasAuthorship W3128333191A5007515910 @default.
- W3128333191 hasAuthorship W3128333191A5026841275 @default.
- W3128333191 hasAuthorship W3128333191A5057964730 @default.
- W3128333191 hasAuthorship W3128333191A5074768497 @default.
- W3128333191 hasAuthorship W3128333191A5076668383 @default.
- W3128333191 hasAuthorship W3128333191A5076729993 @default.
- W3128333191 hasAuthorship W3128333191A5082563570 @default.
- W3128333191 hasBestOaLocation W31283331913 @default.
- W3128333191 hasConcept C113280763 @default.
- W3128333191 hasConcept C126322002 @default.
- W3128333191 hasConcept C126894567 @default.
- W3128333191 hasConcept C134018914 @default.
- W3128333191 hasConcept C159641895 @default.
- W3128333191 hasConcept C2777218474 @default.
- W3128333191 hasConcept C2777799968 @default.
- W3128333191 hasConcept C2777940137 @default.
- W3128333191 hasConcept C2778176769 @default.
- W3128333191 hasConcept C2778319317 @default.
- W3128333191 hasConcept C2779548226 @default.
- W3128333191 hasConcept C2780091579 @default.
- W3128333191 hasConcept C2780306776 @default.
- W3128333191 hasConcept C71924100 @default.
- W3128333191 hasConcept C77411442 @default.
- W3128333191 hasConcept C90924648 @default.
- W3128333191 hasConceptScore W3128333191C113280763 @default.
- W3128333191 hasConceptScore W3128333191C126322002 @default.
- W3128333191 hasConceptScore W3128333191C126894567 @default.
- W3128333191 hasConceptScore W3128333191C134018914 @default.
- W3128333191 hasConceptScore W3128333191C159641895 @default.
- W3128333191 hasConceptScore W3128333191C2777218474 @default.
- W3128333191 hasConceptScore W3128333191C2777799968 @default.
- W3128333191 hasConceptScore W3128333191C2777940137 @default.
- W3128333191 hasConceptScore W3128333191C2778176769 @default.
- W3128333191 hasConceptScore W3128333191C2778319317 @default.