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- W3128338675 abstract "Background: Cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality throughout the world. Atherosclerosis is one of the main contributing factors in CVDs. It is mainly due the accumulation of atherogenic lipids inside the coronary arteries. Dyslipidemia results due to accumulation of triglycerides and cholesterol, leading to abnormalities of low density lipoprotein. Among various factors in cholesterol homeostasis LDL receptor LDLR is greatly influenced by Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9). Aim: This study was aimed to investigate influence of genetic variants of PCSK9 on CVD risk in Punjabi subjects from Faisalabad, Pakistan. Methods: For genotyping, two PCSK9 Single Nucleotide Polymorphisms (SNPs: rs505151 A/G and rs562556 A/G) were selected. In this case control study, PCSK9 SNPs were investigated for their association with CVD in a cohort (healthy controls = 50, CVD patients = 100) of Punjabi subjects. Blood samples were collected and clinically important biochemical parameters were measured. SNPs genotyping was performed by in-house developed allele specific Amplification Refractory Mutation System Polymerase Chain Reaction (ARMS-PCR) assay. Results: From statistical analysis, it was found that ASAT showed significant difference between genotypes of both SNPs (p= <0.0001for rs505151 and p= 0.04 for rs562556). Albumin and total protein showed significant difference for genotypes of rs562556 (p=0.04 and p=0.004). Glucose, SBP and DBP also showed significant difference between genotypes of rs505151 (p= 0.02, p=0.01, p=0.04). Genotypic frequency of rs562556 showed significant (p=0.009) difference between control and CVD patient groups. Conclusion: Polymorphism rs562556 showed significant association with CVD." @default.
- W3128338675 created "2021-02-15" @default.
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- W3128338675 date "2021-03-01" @default.
- W3128338675 modified "2023-10-16" @default.
- W3128338675 title "Investigation of Genetic Variants of PCSK9 and their Impact on Cardiovascular Disorders in Pakistani Patients" @default.
- W3128338675 doi "https://doi.org/10.1016/j.metabol.2020.154540" @default.
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