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- W3128362227 abstract "ABSTRACT Microglial cells are active players in regulating synaptic development and plasticity in the brain. However, how these cells influence the normal functioning of synapses is largely unknown. In this study, we characterized the effects of pharmacological depletion of microglia, achieved by administration of PLX5622, on hippocampal CA3-CA1 synapses of adult wild type mice. Following microglial depletion, we observed a reduction of spontaneous and evoked glutamatergic activity associated with a decrease of dendritic spine density. We also observed the appearance of immature synaptic features accompanied by higher levels of plasticity. In addition, microglia depleted mice showed a deficit in the acquisition of the Novel Object Recognition task. Remarkably, microglial repopulation after PLX5622 withdrawal was associated with the recovery of hippocampal synapses and learning functions. Altogether, these data demonstrate that microglia contribute to normal synaptic functioning in the adult brain and that their removal induces reversible changes in synaptic organization and activity of glutamatergic synapses." @default.
- W3128362227 created "2021-02-15" @default.
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- W3128362227 date "2021-02-02" @default.
- W3128362227 modified "2023-10-15" @default.
- W3128362227 title "Microglia control glutamatergic synapses in the adult mouse hippocampus" @default.
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- W3128362227 cites W1968024448 @default.
- W3128362227 cites W1980789245 @default.
- W3128362227 cites W1981142987 @default.
- W3128362227 cites W1986281170 @default.
- W3128362227 cites W1987239731 @default.
- W3128362227 cites W1996055705 @default.
- W3128362227 cites W1997497060 @default.
- W3128362227 cites W2003493421 @default.
- W3128362227 cites W2008986835 @default.
- W3128362227 cites W2011209444 @default.
- W3128362227 cites W2012010559 @default.
- W3128362227 cites W2019016101 @default.
- W3128362227 cites W2022767998 @default.
- W3128362227 cites W2025498751 @default.
- W3128362227 cites W2033617297 @default.
- W3128362227 cites W2035325710 @default.
- W3128362227 cites W2035653093 @default.
- W3128362227 cites W2038813826 @default.
- W3128362227 cites W2044202654 @default.
- W3128362227 cites W2054675346 @default.
- W3128362227 cites W2062564051 @default.
- W3128362227 cites W2066943555 @default.
- W3128362227 cites W2083606437 @default.
- W3128362227 cites W2087321410 @default.
- W3128362227 cites W2095551600 @default.
- W3128362227 cites W2096500024 @default.
- W3128362227 cites W2099005297 @default.
- W3128362227 cites W2104431737 @default.
- W3128362227 cites W2108891955 @default.
- W3128362227 cites W2120911948 @default.
- W3128362227 cites W2121085475 @default.
- W3128362227 cites W2127381922 @default.
- W3128362227 cites W2137979527 @default.
- W3128362227 cites W2144051724 @default.
- W3128362227 cites W2148389554 @default.
- W3128362227 cites W2151241903 @default.
- W3128362227 cites W2163751922 @default.
- W3128362227 cites W2167022467 @default.
- W3128362227 cites W2169700519 @default.
- W3128362227 cites W2171785899 @default.
- W3128362227 cites W2192281019 @default.
- W3128362227 cites W2252088905 @default.
- W3128362227 cites W2256955303 @default.
- W3128362227 cites W2346538481 @default.
- W3128362227 cites W2520409292 @default.
- W3128362227 cites W2788593837 @default.
- W3128362227 cites W2791700208 @default.
- W3128362227 cites W2792302958 @default.
- W3128362227 cites W2894787694 @default.
- W3128362227 cites W2898726956 @default.
- W3128362227 cites W2901712866 @default.
- W3128362227 cites W2946033659 @default.
- W3128362227 cites W2947647528 @default.
- W3128362227 cites W2949239345 @default.
- W3128362227 cites W2951541013 @default.
- W3128362227 cites W2965768470 @default.
- W3128362227 cites W2989940643 @default.
- W3128362227 cites W3037780343 @default.
- W3128362227 cites W3084214304 @default.
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- W3128362227 doi "https://doi.org/10.1101/2021.02.01.429096" @default.
- W3128362227 hasPublicationYear "2021" @default.
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