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- W3128378645 abstract "Taxus is a botanical source for the anticancer drug taxol (paclitaxel, PTX), first reported in 1971 as a result of bioassay-guided fractionation of active extracts from stem bark samples of T. brevifolia. In this chapter, biological and biochemical studies of Taxaceae medicinal plants are summarized. The molecular phylogenetic relationship of Taxaceae and Cephalotaxaceae is unearthed using chloroplast (cp) markers and nuclear (nr) markers, in combination with morphological and chemotaxonomic evidence. Compared with nr sequences, some cp sequences are more suitable as DNA barcoding markers, and the cp genome sequences are promising super-barcodes. The whole-genome sequencing of Taxus species has not been reported, while the cp genome and nuclear transcriptome of some species have been uncovered. Proteomics studies have been performed in T. media and T. mairei. Cell culture is important in the study of Taxus metabolism and taxane production. Elicitors are used to enhance the taxane biosynthesis in cell culture. The regulations of transcription factors, promoter, transgene, and environmental factors in cellular metabolism are revealed. Taxane producing non-Taxus plants are new pharmaceutical resources worthy of attention. Molecular markers mined from different Taxus species have versatile utilities, for example, in the exploration and application of biodiversity, conservation, and ecology. Taxus cultivation could help alleviate the supply crisis of medicinally important taxanes." @default.
- W3128378645 created "2021-02-15" @default.
- W3128378645 creator A5015250303 @default.
- W3128378645 date "2021-01-01" @default.
- W3128378645 modified "2023-09-23" @default.
- W3128378645 title "Biological and biochemical research of Taxaceae medicinal plants: Road to a healthier life" @default.
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