Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128379228> ?p ?o ?g. }
- W3128379228 endingPage "1527" @default.
- W3128379228 startingPage "1527" @default.
- W3128379228 abstract "Many features of aging result from the incapacity of cells to adapt to stress conditions. When cells are overwhelmed by stress, they can undergo senescence to avoid unrestricted growth of damaged cells. Recent findings have proven that cellular senescence is more than that. A specific grade of senescence promotes embryo development, tissue remodeling and wound healing. However, constant stresses and a weakening immune system can lead to senescence chronicity with aging. The accumulation of senescent cells is directly related to tissue dysfunction and age-related pathologies. Centenarians, the most aged individuals, should accumulate senescent cells and suffer from their deleterious effects, however, they enjoy a compression of morbidity. We have shown that they overexpress B-cell lymphoma-extra large (Bcl-xL). Bcl-xL could avoid an excessive burden of senescent cells through the regulation of intrinsic apoptosis, mitochondrial bioenergetics and oxidative stress. On the other hand, Bcl-xL maintains a fully functional immune system that ensures an efficient clearance of senescent cells. Moreover, there is a paradox, as inhibitors of Bcl-xL have been employed as senolytic agents, which have been shown to protect from aging in animal models. In this review, we aim to discuss how Bcl-xL could modulate senescence-associated harmful effects in centenarians, protecting them from the burden of accumulation of senescent cells." @default.
- W3128379228 created "2021-02-15" @default.
- W3128379228 creator A5037078453 @default.
- W3128379228 creator A5038823686 @default.
- W3128379228 creator A5061232265 @default.
- W3128379228 date "2021-02-03" @default.
- W3128379228 modified "2023-10-14" @default.
- W3128379228 title "Bcl-xL as a Modulator of Senescence and Aging" @default.
- W3128379228 cites W1524549603 @default.
- W3128379228 cites W1548190196 @default.
- W3128379228 cites W1563936556 @default.
- W3128379228 cites W1586529568 @default.
- W3128379228 cites W1677697833 @default.
- W3128379228 cites W1965493795 @default.
- W3128379228 cites W1967776532 @default.
- W3128379228 cites W1969586296 @default.
- W3128379228 cites W1972655555 @default.
- W3128379228 cites W1976635482 @default.
- W3128379228 cites W1977362098 @default.
- W3128379228 cites W1979462186 @default.
- W3128379228 cites W1980523527 @default.
- W3128379228 cites W1982481909 @default.
- W3128379228 cites W1984175331 @default.
- W3128379228 cites W1984796570 @default.
- W3128379228 cites W1987175913 @default.
- W3128379228 cites W1990113206 @default.
- W3128379228 cites W1990572469 @default.
- W3128379228 cites W1993856276 @default.
- W3128379228 cites W1999206742 @default.
- W3128379228 cites W2001965479 @default.
- W3128379228 cites W2004314923 @default.
- W3128379228 cites W2007827117 @default.
- W3128379228 cites W2009668465 @default.
- W3128379228 cites W2010345740 @default.
- W3128379228 cites W2010417927 @default.
- W3128379228 cites W2010706585 @default.
- W3128379228 cites W2013287222 @default.
- W3128379228 cites W2017235640 @default.
- W3128379228 cites W2019906376 @default.
- W3128379228 cites W2022161896 @default.
- W3128379228 cites W2026433865 @default.
- W3128379228 cites W2027931017 @default.
- W3128379228 cites W2029685980 @default.
- W3128379228 cites W2030795773 @default.
- W3128379228 cites W2030943857 @default.
- W3128379228 cites W2033332037 @default.
- W3128379228 cites W2037064466 @default.
- W3128379228 cites W2044347768 @default.
- W3128379228 cites W2047330128 @default.
- W3128379228 cites W2048817820 @default.
- W3128379228 cites W2050551830 @default.
- W3128379228 cites W2052411122 @default.
- W3128379228 cites W2055744703 @default.
- W3128379228 cites W2058365486 @default.
- W3128379228 cites W2059165104 @default.
- W3128379228 cites W2059769704 @default.
- W3128379228 cites W2061075988 @default.
- W3128379228 cites W2063250341 @default.
- W3128379228 cites W2069519394 @default.
- W3128379228 cites W2069701438 @default.
- W3128379228 cites W2071673220 @default.
- W3128379228 cites W2074871320 @default.
- W3128379228 cites W2077450385 @default.
- W3128379228 cites W2082402714 @default.
- W3128379228 cites W2085527248 @default.
- W3128379228 cites W2087404852 @default.
- W3128379228 cites W2090067193 @default.
- W3128379228 cites W2090557792 @default.
- W3128379228 cites W2103530035 @default.
- W3128379228 cites W2104908670 @default.
- W3128379228 cites W2108887402 @default.
- W3128379228 cites W2109017650 @default.
- W3128379228 cites W2111450457 @default.
- W3128379228 cites W2112458458 @default.
- W3128379228 cites W2113044182 @default.
- W3128379228 cites W2114840727 @default.
- W3128379228 cites W2115852450 @default.
- W3128379228 cites W2121077787 @default.
- W3128379228 cites W2126709547 @default.
- W3128379228 cites W2128807350 @default.
- W3128379228 cites W2130458932 @default.
- W3128379228 cites W2131250713 @default.
- W3128379228 cites W2135564059 @default.
- W3128379228 cites W2137309569 @default.
- W3128379228 cites W2139425230 @default.
- W3128379228 cites W2139636031 @default.
- W3128379228 cites W2149362209 @default.
- W3128379228 cites W2150748567 @default.
- W3128379228 cites W2160279897 @default.
- W3128379228 cites W2167244325 @default.
- W3128379228 cites W2193792657 @default.
- W3128379228 cites W2210634983 @default.
- W3128379228 cites W2224270925 @default.
- W3128379228 cites W2224886002 @default.
- W3128379228 cites W2267737556 @default.
- W3128379228 cites W2281263309 @default.
- W3128379228 cites W2283668976 @default.
- W3128379228 cites W2315277092 @default.