FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128397573> ?p ?o ?g. }

• W3128397573 endingPage "738" @default.
• W3128397573 startingPage "726" @default.
• W3128397573 abstract "The oncogenic transcription factor STAT3 is aberrantly activated in 70% of breast cancers, including nearly all triple-negative breast cancers (TNBCs). Because STAT3 is difficult to target directly, we considered whether metabolic changes driven by activated STAT3 could provide a therapeutic opportunity. We found that STAT3 prominently modulated several lipid classes, with most profound effects on N-acyl taurine and arachidonic acid, both of which are involved in plasma membrane remodeling. To exploit these metabolic changes therapeutically, we screened a library of layer-by-layer (LbL) nanoparticles (NPs) differing in the surface layer that modulates interactivity with the cell membrane. We found that poly-l-glutamic acid (PLE)-coated NPs bind to STAT3-transformed breast cancer cells with 50% greater efficiency than to nontransformed cells, and the heightened PLE-NP binding to TNBC cells was attenuated by STAT3 inhibition. This effect was also observed in densely packed three-dimensional breast cancer organoids. As STAT3-transformed cells show greater resistance to cytotoxic agents, we evaluated whether enhanced targeted delivery via PLE-NPs would provide a therapeutic advantage. We found that cisplatin-loaded PLE-NPs induced apoptosis of STAT3-driven cells at lower doses compared with both unencapsulated cisplatin and cisplatin-loaded nontargeted NPs. In addition, because radiation is commonly used in breast cancer treatment, and may alter cellular lipid distribution, we analyzed its effect on PLE-NP-cell binding. Irradiation of cells enhanced the STAT3-targeting properties of PLE-NPs in a dose-dependent manner, suggesting potential synergies between these therapeutic modalities. These findings suggest that cellular lipid changes driven by activated STAT3 may be exploited therapeutically using unique LbL NPs." @default.
• W3128397573 created "2021-02-15" @default.
• W3128397573 creator A5006902424 @default.
• W3128397573 creator A5009134446 @default.
• W3128397573 creator A5011390857 @default.
• W3128397573 creator A5020663996 @default.
• W3128397573 creator A5021455621 @default.
• W3128397573 creator A5035184259 @default.
• W3128397573 creator A5036628698 @default.
• W3128397573 creator A5047880272 @default.
• W3128397573 creator A5048318552 @default.
• W3128397573 creator A5065359511 @default.
• W3128397573 creator A5069094503 @default.
• W3128397573 creator A5084145871 @default.
• W3128397573 creator A5085032736 @default.
• W3128397573 creator A5090066596 @default.
• W3128397573 date "2021-02-03" @default.
• W3128397573 modified "2023-10-18" @default.
• W3128397573 title "Lipidome-based Targeting of STAT3-driven Breast Cancer Cells Using Poly-l-glutamic Acid–coated Layer-by-Layer Nanoparticles" @default.
• W3128397573 cites W1504229889 @default.
• W3128397573 cites W1969512609 @default.
• W3128397573 cites W1986494305 @default.
• W3128397573 cites W2016097990 @default.
• W3128397573 cites W2019491391 @default.
• W3128397573 cites W2032991676 @default.
• W3128397573 cites W2068713081 @default.
• W3128397573 cites W2101454196 @default.
• W3128397573 cites W2104542806 @default.
• W3128397573 cites W2127238287 @default.
• W3128397573 cites W2150375936 @default.
• W3128397573 cites W2153086428 @default.
• W3128397573 cites W2194952020 @default.
• W3128397573 cites W2228664137 @default.
• W3128397573 cites W2279707503 @default.
• W3128397573 cites W2286284214 @default.
• W3128397573 cites W2293079376 @default.
• W3128397573 cites W2331140348 @default.
• W3128397573 cites W2357535822 @default.
• W3128397573 cites W2509469063 @default.
• W3128397573 cites W2566693616 @default.
• W3128397573 cites W2584750294 @default.
• W3128397573 cites W2598009430 @default.
• W3128397573 cites W2742005115 @default.
• W3128397573 cites W2747559128 @default.
• W3128397573 cites W2748259969 @default.
• W3128397573 cites W2753005915 @default.
• W3128397573 cites W2754975448 @default.
• W3128397573 cites W2772250549 @default.
• W3128397573 cites W2786987313 @default.
• W3128397573 cites W2801208163 @default.
• W3128397573 cites W2806628670 @default.
• W3128397573 cites W2810763069 @default.
• W3128397573 cites W2889681007 @default.
• W3128397573 cites W2911188335 @default.
• W3128397573 cites W2913467766 @default.
• W3128397573 cites W2921768356 @default.
• W3128397573 cites W2936110492 @default.
• W3128397573 cites W2938872243 @default.
• W3128397573 cites W2946899637 @default.
• W3128397573 cites W2965425949 @default.
• W3128397573 cites W2970984058 @default.
• W3128397573 cites W2989744634 @default.
• W3128397573 cites W2998891465 @default.
• W3128397573 cites W3002758941 @default.
• W3128397573 cites W3004526380 @default.
• W3128397573 cites W3009077651 @default.
• W3128397573 cites W3013263185 @default.
• W3128397573 cites W3035964337 @default.
• W3128397573 doi "https://doi.org/10.1158/1535-7163.mct-20-0505" @default.
• W3128397573 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8026705" @default.
• W3128397573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33536189" @default.
• W3128397573 hasPublicationYear "2021" @default.
• W3128397573 type Work @default.
• W3128397573 sameAs 3128397573 @default.
• W3128397573 citedByCount "4" @default.
• W3128397573 countsByYear W31283975732021 @default.
• W3128397573 countsByYear W31283975732023 @default.
• W3128397573 crossrefType "journal-article" @default.
• W3128397573 hasAuthorship W3128397573A5006902424 @default.
• W3128397573 hasAuthorship W3128397573A5009134446 @default.
• W3128397573 hasAuthorship W3128397573A5011390857 @default.
• W3128397573 hasAuthorship W3128397573A5020663996 @default.
• W3128397573 hasAuthorship W3128397573A5021455621 @default.
• W3128397573 hasAuthorship W3128397573A5035184259 @default.
• W3128397573 hasAuthorship W3128397573A5036628698 @default.
• W3128397573 hasAuthorship W3128397573A5047880272 @default.
• W3128397573 hasAuthorship W3128397573A5048318552 @default.
• W3128397573 hasAuthorship W3128397573A5065359511 @default.
• W3128397573 hasAuthorship W3128397573A5069094503 @default.
• W3128397573 hasAuthorship W3128397573A5084145871 @default.
• W3128397573 hasAuthorship W3128397573A5085032736 @default.
• W3128397573 hasAuthorship W3128397573A5090066596 @default.
• W3128397573 hasBestOaLocation W31283975731 @default.
• W3128397573 hasConcept C121608353 @default.
• W3128397573 hasConcept C185592680 @default.
• W3128397573 hasConcept C190283241 @default.
• W3128397573 hasConcept C2776694085 @default.
• W3128397573 hasConcept C2778239845 @default.

• next