FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128403904> ?p ?o ?g. }

• W3128403904 abstract "Depression is a common mental disorder that presents a considerable challenge for public health. The natural product geniposide has neuroprotective effects on depression, but the underlying mechanism behind these effects had remained undefined. The present study was designed to investigate the role of microRNAs (miRs) in this mechanism. It studied mice with depression-like behavior established by exposure to chronic unpredictable mild stress (CUMS) for 2 months. The CUMS mice were intragastrically fed with geniposide at a dose of 10 ml/kg daily for two consecutive weeks. We monitored the depression-like behaviors of the CUMS mice by the forced swimming test (FST) and tail suspension test (TST). Then, we measured the cerebral expression of miR-298-5p and NADPH oxidase 1 (Nox1) mRNA in the CUMS mice by the RT-qPCR. The targeting relationship between miR-298-5p and Nox1 was evaluated by dual-luciferase reporter gene assay. The concentrations of adenosine triphosphate (ATP) and reactive oxygen species (ROS) were determined by the CellTiter-Glo ® and flow cytometry, respectively. The mitochondrial membrane potential (MMP) was detected using JC-1 staining. Moreover, the expression of inflammatory cytokines (TNF-α, IL-1β, IL-6, and TGF-β) was determined by ELISA, RT-qPCR, and western blot analysis. We found that miR-298-5p was poorly-expressed while Nox1 was highly-expressed in the brain tissues of the CUMS-induced mice. Intriguingly, Geniposide treatment reversed the behavioral abnormalities of CUMS mice, including shortened immobility time. Geniposide inhibited the Nox1 expression by increasing miR-298-5p levels. There were increased ATP content and MMP and reduced contents of ROS and inflammatory cytokines in the CUMS mice receiving geniposide treatment. Hence, this study revealed an antidepressant effect of geniposide on CUMS-induced depression-like behavior in mice by down-regulating the miR-298-5p-targeted Nox1. This highlights a novel candidate target for the treatment of depression." @default.
• W3128403904 created "2021-02-15" @default.
• W3128403904 creator A5002278105 @default.
• W3128403904 creator A5009582070 @default.
• W3128403904 creator A5028190971 @default.
• W3128403904 creator A5032025930 @default.
• W3128403904 creator A5048817987 @default.
• W3128403904 creator A5055616913 @default.
• W3128403904 date "2021-02-03" @default.
• W3128403904 modified "2023-10-16" @default.
• W3128403904 title "Antidepressant-Like Effect of Geniposide in Mice Exposed to a Chronic Mild Stress Involves the microRNA-298-5p-Mediated Nox1" @default.
• W3128403904 cites W1982893010 @default.
• W3128403904 cites W1992958350 @default.
• W3128403904 cites W2013223518 @default.
• W3128403904 cites W2044613993 @default.
• W3128403904 cites W2059329303 @default.
• W3128403904 cites W2081991273 @default.
• W3128403904 cites W2084158133 @default.
• W3128403904 cites W2094716466 @default.
• W3128403904 cites W2103219879 @default.
• W3128403904 cites W2117600285 @default.
• W3128403904 cites W2159155742 @default.
• W3128403904 cites W2195669615 @default.
• W3128403904 cites W2284262522 @default.
• W3128403904 cites W2431256774 @default.
• W3128403904 cites W2508367806 @default.
• W3128403904 cites W2508614423 @default.
• W3128403904 cites W2517739734 @default.
• W3128403904 cites W2574254633 @default.
• W3128403904 cites W2578653340 @default.
• W3128403904 cites W2582903515 @default.
• W3128403904 cites W2596853977 @default.
• W3128403904 cites W2601308787 @default.
• W3128403904 cites W2617110785 @default.
• W3128403904 cites W2622935878 @default.
• W3128403904 cites W2760157782 @default.
• W3128403904 cites W2760643559 @default.
• W3128403904 cites W2792832613 @default.
• W3128403904 cites W2794690721 @default.
• W3128403904 cites W2796364626 @default.
• W3128403904 cites W2802830659 @default.
• W3128403904 cites W2804926955 @default.
• W3128403904 cites W2883931951 @default.
• W3128403904 cites W2887725539 @default.
• W3128403904 cites W2890430536 @default.
• W3128403904 cites W2895960152 @default.
• W3128403904 cites W2902683674 @default.
• W3128403904 cites W2902980710 @default.
• W3128403904 cites W2903259912 @default.
• W3128403904 cites W2904597631 @default.
• W3128403904 cites W2913186662 @default.
• W3128403904 cites W2957931514 @default.
• W3128403904 cites W2979167457 @default.
• W3128403904 cites W4211263234 @default.
• W3128403904 doi "https://doi.org/10.3389/fnmol.2020.00131" @default.
• W3128403904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7886707" @default.
• W3128403904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33613190" @default.
• W3128403904 hasPublicationYear "2021" @default.
• W3128403904 type Work @default.
• W3128403904 sameAs 3128403904 @default.
• W3128403904 citedByCount "11" @default.
• W3128403904 countsByYear W31284039042021 @default.
• W3128403904 countsByYear W31284039042022 @default.
• W3128403904 countsByYear W31284039042023 @default.
• W3128403904 crossrefType "journal-article" @default.
• W3128403904 hasAuthorship W3128403904A5002278105 @default.
• W3128403904 hasAuthorship W3128403904A5009582070 @default.
• W3128403904 hasAuthorship W3128403904A5028190971 @default.
• W3128403904 hasAuthorship W3128403904A5032025930 @default.
• W3128403904 hasAuthorship W3128403904A5048817987 @default.
• W3128403904 hasAuthorship W3128403904A5055616913 @default.
• W3128403904 hasBestOaLocation W31284039041 @default.
• W3128403904 hasConcept C104317684 @default.
• W3128403904 hasConcept C126322002 @default.
• W3128403904 hasConcept C136569192 @default.
• W3128403904 hasConcept C145059251 @default.
• W3128403904 hasConcept C185592680 @default.
• W3128403904 hasConcept C25498285 @default.
• W3128403904 hasConcept C2776061955 @default.
• W3128403904 hasConcept C2776151105 @default.
• W3128403904 hasConcept C2776415932 @default.
• W3128403904 hasConcept C2778875871 @default.
• W3128403904 hasConcept C2779177272 @default.
• W3128403904 hasConcept C2779719074 @default.
• W3128403904 hasConcept C2781001258 @default.
• W3128403904 hasConcept C2781161787 @default.
• W3128403904 hasConcept C48349386 @default.
• W3128403904 hasConcept C55493867 @default.
• W3128403904 hasConcept C71924100 @default.
• W3128403904 hasConcept C98274493 @default.
• W3128403904 hasConceptScore W3128403904C104317684 @default.
• W3128403904 hasConceptScore W3128403904C126322002 @default.
• W3128403904 hasConceptScore W3128403904C136569192 @default.
• W3128403904 hasConceptScore W3128403904C145059251 @default.
• W3128403904 hasConceptScore W3128403904C185592680 @default.
• W3128403904 hasConceptScore W3128403904C25498285 @default.
• W3128403904 hasConceptScore W3128403904C2776061955 @default.
• W3128403904 hasConceptScore W3128403904C2776151105 @default.
• W3128403904 hasConceptScore W3128403904C2776415932 @default.
• W3128403904 hasConceptScore W3128403904C2778875871 @default.

• next