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- W3128404735 abstract "Toll-Like Receptor 9 (TLR9) is an ancient receptor integral to the primordial functions of inflammation and metabolism. TLR9 functions to regulate homeostasis in a healthy system under acute stress. The literature supports that overactivation of TLR9 under the chronic stress of obesity is a critical driver of the pathogenesis of NASH and NASH-associated fibrosis. Research has focused on the core contributions of the parenchymal and non-parenchymal cells in the liver, adipose, and gut compartments. TLR9 is activated by endogenous circulating mitochondrial DNA (mtDNA). Chronically elevated circulating levels of mtDNA, caused by the stress of overnutrition, are observed in obesity, metabolic dysfunction-associated fatty liver disease (MAFLD), and NASH. Clinical evidence is supportive of TLR9 overactivation as a driver of disease. The role of TLR9 in metabolism and energy regulation may have an underappreciated contribution in the pathogenesis of NASH. Antagonism of TLR9 in NASH and NASH-associated fibrosis could be an effective therapeutic strategy to target both the inflammatory and metabolic components of such a complex disease." @default.
- W3128404735 created "2021-02-15" @default.
- W3128404735 creator A5030529768 @default.
- W3128404735 date "2021-01-29" @default.
- W3128404735 modified "2023-10-18" @default.
- W3128404735 title "TLR9 in MAFLD and NASH: At the Intersection of Inflammation and Metabolism" @default.
- W3128404735 cites W144306197 @default.
- W3128404735 cites W1491642133 @default.
- W3128404735 cites W1514540900 @default.
- W3128404735 cites W1552634226 @default.
- W3128404735 cites W1558228229 @default.
- W3128404735 cites W169476524 @default.
- W3128404735 cites W173084735 @default.
- W3128404735 cites W1853350807 @default.
- W3128404735 cites W1856151485 @default.
- W3128404735 cites W1877684281 @default.
- W3128404735 cites W1904658532 @default.
- W3128404735 cites W1953460679 @default.
- W3128404735 cites W1964286278 @default.
- W3128404735 cites W1966420007 @default.
- W3128404735 cites W1968862738 @default.
- W3128404735 cites W1970853163 @default.
- W3128404735 cites W1973399759 @default.
- W3128404735 cites W1973847028 @default.
- W3128404735 cites W1975275391 @default.
- W3128404735 cites W1976424894 @default.
- W3128404735 cites W1976740634 @default.
- W3128404735 cites W1976750335 @default.
- W3128404735 cites W1976887761 @default.
- W3128404735 cites W1982060126 @default.
- W3128404735 cites W1983933673 @default.
- W3128404735 cites W1984421836 @default.
- W3128404735 cites W1984595457 @default.
- W3128404735 cites W1985226513 @default.
- W3128404735 cites W1986367878 @default.
- W3128404735 cites W1986740905 @default.
- W3128404735 cites W1986781079 @default.
- W3128404735 cites W1986865930 @default.
- W3128404735 cites W1991418047 @default.
- W3128404735 cites W1993781414 @default.
- W3128404735 cites W1994784206 @default.
- W3128404735 cites W1995586746 @default.
- W3128404735 cites W1996180976 @default.
- W3128404735 cites W1997977259 @default.
- W3128404735 cites W1998972875 @default.
- W3128404735 cites W2002024809 @default.
- W3128404735 cites W2004196710 @default.
- W3128404735 cites W2006396039 @default.
- W3128404735 cites W2009121422 @default.
- W3128404735 cites W2009519656 @default.
- W3128404735 cites W2010808721 @default.
- W3128404735 cites W2010987575 @default.
- W3128404735 cites W2014864120 @default.
- W3128404735 cites W2015171350 @default.
- W3128404735 cites W2015273881 @default.
- W3128404735 cites W2016758939 @default.
- W3128404735 cites W2018252914 @default.
- W3128404735 cites W2018560551 @default.
- W3128404735 cites W2022267544 @default.
- W3128404735 cites W2022337152 @default.
- W3128404735 cites W2022803835 @default.
- W3128404735 cites W2023542511 @default.
- W3128404735 cites W2023655124 @default.
- W3128404735 cites W2024305850 @default.
- W3128404735 cites W2025237130 @default.
- W3128404735 cites W2027163190 @default.
- W3128404735 cites W2032276597 @default.
- W3128404735 cites W2033425827 @default.
- W3128404735 cites W2034188980 @default.
- W3128404735 cites W2036813330 @default.
- W3128404735 cites W2037436187 @default.
- W3128404735 cites W2042433863 @default.
- W3128404735 cites W2042939195 @default.
- W3128404735 cites W2043636143 @default.
- W3128404735 cites W2045497589 @default.
- W3128404735 cites W2045911846 @default.
- W3128404735 cites W2046649601 @default.
- W3128404735 cites W2051327133 @default.
- W3128404735 cites W2054531769 @default.
- W3128404735 cites W2056254683 @default.
- W3128404735 cites W2057148652 @default.
- W3128404735 cites W2059330831 @default.
- W3128404735 cites W2059739926 @default.
- W3128404735 cites W2065697164 @default.
- W3128404735 cites W2066344307 @default.
- W3128404735 cites W2066727736 @default.
- W3128404735 cites W2067756762 @default.
- W3128404735 cites W2068041970 @default.
- W3128404735 cites W2070816084 @default.
- W3128404735 cites W2070827125 @default.
- W3128404735 cites W2073453630 @default.
- W3128404735 cites W2076080662 @default.
- W3128404735 cites W2078210389 @default.
- W3128404735 cites W2079326842 @default.
- W3128404735 cites W2080358144 @default.
- W3128404735 cites W2081062357 @default.
- W3128404735 cites W2082119880 @default.
- W3128404735 cites W2083052522 @default.
- W3128404735 cites W2086714780 @default.
- W3128404735 cites W2090640877 @default.