Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128448084> ?p ?o ?g. }
- W3128448084 endingPage "271" @default.
- W3128448084 startingPage "255" @default.
- W3128448084 abstract "The normal functioning of eukaryotic cells depends on the compartmentalization of metabolic processes within specific organelles. Interactions among organelles, such as those between the endoplasmic reticulum (ER) - considered the largest single structure in eukaryotic cells - and other organelles at membrane contact sites (MCSs) have also been suggested to trigger synergisms, including intracellular immune responses against pathogens. In addition to the ER-endogenous functions and ER-organelle MCSs, we present the perspective of a third-order role of the ER as a host contact site for endosymbiotic microbial non-pathogens and pathogens, from endosymbiont bacteria to parasitic protists and viruses. Although understudied, ER-endosymbiont interactions have been observed in a range of eukaryotic hosts, including protists, plants, algae, and metazoans. Host ER interactions with endosymbionts could be an ER function built from ancient, conserved mechanisms selected for communicating with mutualistic endosymbionts in specific life cycle stages, and they may be exploited by pathogens and parasites. The host ER-'guest' interactome and traits in endosymbiotic biology are briefly discussed. The acknowledgment and understanding of these possible mechanisms might reveal novel evolutionary perspectives, uncover the causes of unexplained cellular disorders and suggest new pharmacological targets." @default.
- W3128448084 created "2021-02-15" @default.
- W3128448084 creator A5089238182 @default.
- W3128448084 date "2021-02-22" @default.
- W3128448084 modified "2023-09-23" @default.
- W3128448084 title "A potential third‐order role of the host endoplasmic reticulum as a contact site in interkingdom microbial endosymbiosis and viral infection" @default.
- W3128448084 cites W1494745142 @default.
- W3128448084 cites W1619107059 @default.
- W3128448084 cites W1697178647 @default.
- W3128448084 cites W1703681993 @default.
- W3128448084 cites W1804573660 @default.
- W3128448084 cites W183858582 @default.
- W3128448084 cites W1849034023 @default.
- W3128448084 cites W1875548058 @default.
- W3128448084 cites W1885388687 @default.
- W3128448084 cites W1950028738 @default.
- W3128448084 cites W1953178180 @default.
- W3128448084 cites W1968684038 @default.
- W3128448084 cites W1970815708 @default.
- W3128448084 cites W1971411282 @default.
- W3128448084 cites W1971817619 @default.
- W3128448084 cites W1971972481 @default.
- W3128448084 cites W1972700607 @default.
- W3128448084 cites W1974865581 @default.
- W3128448084 cites W1975481567 @default.
- W3128448084 cites W1976215395 @default.
- W3128448084 cites W1980381656 @default.
- W3128448084 cites W1980775568 @default.
- W3128448084 cites W1981276113 @default.
- W3128448084 cites W1983810850 @default.
- W3128448084 cites W1985244199 @default.
- W3128448084 cites W1985606869 @default.
- W3128448084 cites W1990209435 @default.
- W3128448084 cites W1991263428 @default.
- W3128448084 cites W1994802875 @default.
- W3128448084 cites W1997313407 @default.
- W3128448084 cites W2002575820 @default.
- W3128448084 cites W2002803275 @default.
- W3128448084 cites W2003991742 @default.
- W3128448084 cites W2006002292 @default.
- W3128448084 cites W2007921798 @default.
- W3128448084 cites W2010186603 @default.
- W3128448084 cites W2010958659 @default.
- W3128448084 cites W2012539422 @default.
- W3128448084 cites W2015070570 @default.
- W3128448084 cites W2017175357 @default.
- W3128448084 cites W2017267009 @default.
- W3128448084 cites W2018119834 @default.
- W3128448084 cites W2019852490 @default.
- W3128448084 cites W2020139867 @default.
- W3128448084 cites W2020432967 @default.
- W3128448084 cites W2021161083 @default.
- W3128448084 cites W2022174079 @default.
- W3128448084 cites W2024027753 @default.
- W3128448084 cites W2024691983 @default.
- W3128448084 cites W2029987169 @default.
- W3128448084 cites W2030555694 @default.
- W3128448084 cites W2032362466 @default.
- W3128448084 cites W2034718656 @default.
- W3128448084 cites W2035489363 @default.
- W3128448084 cites W2040416009 @default.
- W3128448084 cites W2044965986 @default.
- W3128448084 cites W2046377789 @default.
- W3128448084 cites W2047808004 @default.
- W3128448084 cites W2058491590 @default.
- W3128448084 cites W2060804705 @default.
- W3128448084 cites W2062164045 @default.
- W3128448084 cites W2062197104 @default.
- W3128448084 cites W2063747538 @default.
- W3128448084 cites W2065188354 @default.
- W3128448084 cites W2068128206 @default.
- W3128448084 cites W2071990248 @default.
- W3128448084 cites W2075046123 @default.
- W3128448084 cites W2075274127 @default.
- W3128448084 cites W2076034521 @default.
- W3128448084 cites W2077187477 @default.
- W3128448084 cites W2078263624 @default.
- W3128448084 cites W2080851356 @default.
- W3128448084 cites W2083860481 @default.
- W3128448084 cites W2083968498 @default.
- W3128448084 cites W2091439201 @default.
- W3128448084 cites W2097659338 @default.
- W3128448084 cites W2098293220 @default.
- W3128448084 cites W2104352786 @default.
- W3128448084 cites W2104943222 @default.
- W3128448084 cites W2105891409 @default.
- W3128448084 cites W2108463591 @default.
- W3128448084 cites W2109735813 @default.
- W3128448084 cites W2113356280 @default.
- W3128448084 cites W2113983712 @default.
- W3128448084 cites W2116004188 @default.
- W3128448084 cites W2116448293 @default.
- W3128448084 cites W2117259588 @default.
- W3128448084 cites W2118012320 @default.
- W3128448084 cites W2119203909 @default.
- W3128448084 cites W2119815654 @default.
- W3128448084 cites W2120022312 @default.
- W3128448084 cites W2122550753 @default.