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- W3128473016 abstract "Abstract The distribution of cellular resources across bacterial proteins has been quantified through phenomenological growth laws. Here, we describe a complementary bacterial growth law for RNA composition, emerging from optimal cellular resource allocation into ribosomes and ternary complexes. The predicted decline of the tRNA/rRNA ratio with growth rate agrees quantitatively with experimental data. Its regulation appears to be implemented in part through chromosomal localization, as rRNA genes are typically closer to the origin of replication than tRNA genes and thus have increasingly higher gene dosage at faster growth. At the highest growth rates in E. coli , the tRNA/rRNA ratio appears to be regulated entirely through this effect." @default.
- W3128473016 created "2021-02-15" @default.
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- W3128473016 date "2021-02-06" @default.
- W3128473016 modified "2023-10-18" @default.
- W3128473016 title "An optimal growth law for RNA composition and its partial implementation through ribosomal and tRNA gene locations in bacterial genomes" @default.
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- W3128473016 doi "https://doi.org/10.1101/2021.02.05.429890" @default.
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