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• W3128496489 abstract "The implant design in total knee replacement affects postoperative functionality greatly, therefore, its optimization is of major concern. However, little is known about how implant design parameters affect active knee kinematics. Comprehensive in silico and in vitro sensitivity analyses were performed, based on one patient-specific, physical knee implant set and corresponding bone and knee implant surface geometry data. The implant surfaces were parametrized and varied systematically, resulting in 85 different knee implant surface models. In addition, four variations of extensor mechanism parameters, being the muscular attachment points defining the Q-Angle, were investigated. The variations were evaluated in a patient-specific multibody simulation model and an experimental testing rig and contributions of different implant designs and extensor mechanism parameters on kinematics were analysed. The results of the in silico and in vitro analyses showed good qualitative agreement. The highest deviations from the implant’s reference kinematics were found for parameter variations of the femoral sagittal radii, the lateral trochlear elevation, the tibial sagittal slopes, the mediolateral position of the patellar ridge and the mediolateral position of the tuberositas tibiae. The implant design parameters identified with the highest functional relevance should be focused on in implant design. As the tuberositas tibiae’s position constituted a main impact factor, it should also be considered during implant design and preoperative planning. Due to the competing influence of implant design parameters on active kinematics, respective parameters should be designed which are compatible to each other to avoid adverse constraints and associated functional limitations." @default.
• W3128496489 created "2021-02-15" @default.
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• W3128496489 date "2021-04-01" @default.
• W3128496489 modified "2023-10-02" @default.
• W3128496489 title "Relationship between the form and function of implant design in total knee replacement" @default.
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• W3128496489 doi "https://doi.org/10.1016/j.jbiomech.2021.110296" @default.
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