FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128504046> ?p ?o ?g. }

• W3128504046 abstract "Lipid rafts are functional membrane microdomains containing sphingolipids, including gangliosides, and cholesterol. These regions are characterized by highly ordered and tightly packed lipid molecules. Several studies revealed that lipid rafts are involved in life cycle of different viruses, including coronaviruses. Among these recently emerged the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The main receptor for SARS-CoV-2 is represented by the angiotensin-converting enzyme-2 (ACE-2), although it also binds to sialic acids linked to host cell surface gangliosides. A new type of ganglioside-binding domain within the N-terminal portion of the SARS-CoV-2 spike protein was identified. Lipid rafts provide a suitable platform able to concentrate ACE-2 receptor on host cell membranes where they may interact with the spike protein on viral envelope. This review is focused on selective targeting lipid rafts components as a strategy against coronavirus. Indeed, cholesterol-binding agents, including statins or methyl-β-cyclodextrin (MβCD), can affect cholesterol, causing disruption of lipid rafts, consequently impairing coronavirus adhesion and binding. Moreover, these compounds can block downstream key molecules in virus infectivity, reducing the levels of proinflammatory molecules [tumor necrosis factor alpha (TNF-α), interleukin (IL)-6], and/or affecting the autophagic process involved in both viral replication and clearance. Furthermore, cyclodextrins can assemble into complexes with various drugs to form host–guest inclusions and may be used as pharmaceutical excipients of antiviral compounds, such as lopinavir and remdesivir, by improving bioavailability and solubility. In conclusion, the role of lipid rafts-affecting drugs in the process of coronavirus entry into the host cells prompts to introduce a new potential task in the pharmacological approach against coronavirus." @default.
• W3128504046 created "2021-02-15" @default.
• W3128504046 creator A5004688595 @default.
• W3128504046 creator A5016703211 @default.
• W3128504046 creator A5048821169 @default.
• W3128504046 creator A5060904495 @default.
• W3128504046 creator A5071368565 @default.
• W3128504046 creator A5073735460 @default.
• W3128504046 creator A5078388130 @default.
• W3128504046 creator A5090308798 @default.
• W3128504046 date "2021-02-04" @default.
• W3128504046 modified "2023-10-05" @default.
• W3128504046 title "Targeting Lipid Rafts as a Strategy Against Coronavirus" @default.
• W3128504046 cites W1559770280 @default.
• W3128504046 cites W1909441690 @default.
• W3128504046 cites W1944155216 @default.
• W3128504046 cites W1972814033 @default.
• W3128504046 cites W1980337527 @default.
• W3128504046 cites W1980904413 @default.
• W3128504046 cites W1981739062 @default.
• W3128504046 cites W1982294781 @default.
• W3128504046 cites W1987002413 @default.
• W3128504046 cites W2000030956 @default.
• W3128504046 cites W2000621526 @default.
• W3128504046 cites W2010733432 @default.
• W3128504046 cites W2012893948 @default.
• W3128504046 cites W2015752928 @default.
• W3128504046 cites W2016689892 @default.
• W3128504046 cites W2017451770 @default.
• W3128504046 cites W2021211941 @default.
• W3128504046 cites W2030140279 @default.
• W3128504046 cites W2035171259 @default.
• W3128504046 cites W2036428031 @default.
• W3128504046 cites W2038905366 @default.
• W3128504046 cites W2044679869 @default.
• W3128504046 cites W2051062943 @default.
• W3128504046 cites W2052622892 @default.
• W3128504046 cites W2053528586 @default.
• W3128504046 cites W2053599433 @default.
• W3128504046 cites W2055154266 @default.
• W3128504046 cites W2055199576 @default.
• W3128504046 cites W2058290041 @default.
• W3128504046 cites W2061664912 @default.
• W3128504046 cites W2063103774 @default.
• W3128504046 cites W2063180263 @default.
• W3128504046 cites W2063693562 @default.
• W3128504046 cites W2065433424 @default.
• W3128504046 cites W2065886456 @default.
• W3128504046 cites W2069856609 @default.
• W3128504046 cites W2072274588 @default.
• W3128504046 cites W2074916511 @default.
• W3128504046 cites W2075262517 @default.
• W3128504046 cites W2093132593 @default.
• W3128504046 cites W2093353665 @default.
• W3128504046 cites W2094241924 @default.
• W3128504046 cites W2094356159 @default.
• W3128504046 cites W2098329073 @default.
• W3128504046 cites W2105149323 @default.
• W3128504046 cites W2107251417 @default.
• W3128504046 cites W2110364669 @default.
• W3128504046 cites W2113888821 @default.
• W3128504046 cites W2121936687 @default.
• W3128504046 cites W2124159817 @default.
• W3128504046 cites W2124720109 @default.
• W3128504046 cites W2136558879 @default.
• W3128504046 cites W2138107224 @default.
• W3128504046 cites W2139340707 @default.
• W3128504046 cites W2140533301 @default.
• W3128504046 cites W2140900740 @default.
• W3128504046 cites W2146145365 @default.
• W3128504046 cites W2154836432 @default.
• W3128504046 cites W2160063693 @default.
• W3128504046 cites W2161337022 @default.
• W3128504046 cites W2166131107 @default.
• W3128504046 cites W2167089499 @default.
• W3128504046 cites W2239517876 @default.
• W3128504046 cites W2290093294 @default.
• W3128504046 cites W2344348455 @default.
• W3128504046 cites W2346550589 @default.
• W3128504046 cites W2470646526 @default.
• W3128504046 cites W2472925387 @default.
• W3128504046 cites W2507698120 @default.
• W3128504046 cites W2572357090 @default.
• W3128504046 cites W2599649240 @default.
• W3128504046 cites W2769163026 @default.
• W3128504046 cites W2773913053 @default.
• W3128504046 cites W2789667300 @default.
• W3128504046 cites W2791778515 @default.
• W3128504046 cites W2793008036 @default.
• W3128504046 cites W2793957501 @default.
• W3128504046 cites W2797826108 @default.
• W3128504046 cites W2801061236 @default.
• W3128504046 cites W2890011138 @default.
• W3128504046 cites W2897035420 @default.
• W3128504046 cites W2903899730 @default.
• W3128504046 cites W2907960228 @default.
• W3128504046 cites W2910366576 @default.
• W3128504046 cites W2959238846 @default.
• W3128504046 cites W2963447008 @default.
• W3128504046 cites W2964321733 @default.

• next