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• W3128526095 abstract "Abstract Acquired thrombotic thrombocytopenic purpura (aTTP) is still associated with a 10% to 20% death rate and its clinical course is characterized by recurrent episodes in up to 50% of cases. Over the last decade, mortality predicting models like the French TMA Reference Center Score and the Mortality In TTP Score (MITS) have been developed in an attempt to personalize treatment. The objective of the present study was to compare the results in both scores of de novo and relapsed aTTP episodes. For such purpose, a total of 29 episodes of aTTP (16 de novo and 13 relapses) were analyzed. All patients were homogeneously diagnosed and treated. First episodes had a higher score in both models in comparison with relapsed aTTP, ( MITS median, 1 r : 1‐4 vs 0 r : 1‐2, P = .038 and French TMA Reference Center Score median, 2 r : 1‐3 vs 1 r : 0‐1, P = .006). The prevalence of neurological symptoms was significantly higher in the first episodes ( P = .001) and patients >60 years old were more common in this group ( P = .013), which may have been related to the results. Platelet count at presentation was higher in recurrences than in the first disease episode ( P = .016) and ADAMTS13 activity <5% was more frequent in the last group ( P = .016). There was no significant difference in the rate of refractoriness or exacerbations. In conclusion, first aTTP episodes had a higher probability of short‐term mortality compared to relapsed aTTP episodes according to the MITS and French TMA Reference Center Score ." @default.
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• W3128526095 date "2021-02-03" @default.
• W3128526095 modified "2023-10-18" @default.
• W3128526095 title "Application of the French <scp>TMA</scp> Reference Center Score and the mortality in <scp>TTP Score</scp> in de novo and relapsed episodes of acquired <scp>thrombotic thrombocytopenic purpura</scp> at a tertiary care facility in Spain" @default.
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• W3128526095 doi "https://doi.org/10.1002/jca.21880" @default.
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