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- W3128542633 abstract "Background: To determine the preventive effect of Green Tea Extract (GTE) supplements on metachronous colorectal adenoma and cancer by giving GTE tablets which are equivalent of 9 cup-of-green tea per day (0.9 g/day GTE, 0.6 g/day epigallocatechin gallate [EGCG]). Methods: The subjects who had undergone complete removal of colorectal adenomas by endoscopic polypectomy were enrolled. They were then randomized into two groups: supplementation group (0.9 g GTE per day for 12 months) or control group without GTE supplementation. Follow-up colonoscopy was conducted in 12 months. A sample size of 176 patients (88 per each group) considering 20 % loss to follow-up was calculated to give the study 80% power to detect a difference, assuming a two-sided signifi cance test at the 0.05 level. From June 2010 to May 2014, 121 patients (67 patients with GTE supplementation and 54 controls) completed the study protocol. Results: Of the 121 patients enrolled in the study, the incidences of metachronous polyps at the end-point colonoscopy were 57.9 % (33 of 54) in control group and 25.4 % (17 of 67) in GTE group (relative risk [RR], 0.25; 95% confi dence interval [CI], 0.12 - 0.53). Occurrences of metachronous adenoma showed a decrease in GTE group (22.4 %, 15 of 67) compared to control group (42.1 %, 24 of 54; RR, 0.40; 95% CI, 0.18 - 0.86); the number of relapsed adenoma was also decreased in the GTE group than in the control group (0.3 ± 0.6 vs. 0.7 ± 1.1, P = 0.028). There were no signifi cant fi ndings regarding serum lipid profi les, fasting serum glucose and serum C-reactive protein levels in the two groups. Conclusions: This pilot study of GTE supplement suggests a favorable outcome for the chemoprevention of metachronous colorectal adenomas in Korean patients." @default.
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- W3128542633 date "2014-01-01" @default.
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- W3128542633 title "Poster Session : PS 0919 ; Lower GI Tract : Green Tea Extracts for the Prevention of Colorectal Adenoma and Colorectal Cancer" @default.
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