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• W3128559550 endingPage "100910" @default.
• W3128559550 startingPage "100910" @default.
• W3128559550 abstract "The prevalence of sexual reproduction in most animal species despite its considerable costs such as useless males, energy spent on mating, the cost of meiosis and genome dilution remains a puzzle in evolutionary theory. One prominent single factor attempt to solve this persistent puzzle is the claim that sexual reproduction is instrumental in eliminating deleterious alleles from the species genome by the mechanism of recombination. There are three major versions of the deleterious allele hypothesis: First, the mutational deterministic hypothesis (MDH), which rests on the assumption of negative epistasis, predicts that recombination will help to purge the species genome of deleterious alleles by breaking apart linkages between these alleles. The assumption is that the joint negative effects of linked deleterious alleles is sometimes greater than the effects of the alleles considered separately. Second, there is the hypothesis that sexual reproduction speeds up purifying (negative) selection, which purges the genome of deleterious alleles. Alleles that are less deleterious than the wild type are naturally selected. These alleles, attained via recombination, are sometimes ‘leaky’ mutations giving rise to reduced functionality of attendant proteins. This hypothesis does not necessarily rest on the assumption of negative epistasis, which some argue is relatively rare in nature (Kouyos, Silander and Bonhoeffer (2012)) and which arguably could be seen as a virtue of the purifying selection hypothesis vs. the MDH. Third, Muller's ratchet hypothesis predicts that recombination will help to prevent the buildup of deleterious mutations by the mechanism of recombination. In this study, we focus primarily on testing the purifying selection hypothesis. We performed an individual-based model computer simulation using the program EcoSim to test this hypothesis. The experimental runs for sexual reproduction, asexual reproduction and facultative reproduction involved introducing a deleterious allele into the genome, which exacts an intermediate-level energy penalty on individuals. It was found that whereas on average, deleteriousness consistently declined over 18,000 time-steps due to recombination in sexual reproduction, deleteriousness did not decline for asexual and facultative runs. These results corroborate the hypothesis that recombination due to sexual reproduction helps to eliminate deleterious alleles from the genome through the selection of reduced function mutations." @default.
• W3128559550 created "2021-02-15" @default.
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• W3128559550 date "2021-01-01" @default.
• W3128559550 modified "2023-09-29" @default.
• W3128559550 title "Sex and recombination purge the genome of deleterious alleles: An Individual Based Modeling Approach" @default.
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• W3128559550 doi "https://doi.org/10.1016/j.ecocom.2021.100910" @default.
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