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- W3128567057 endingPage "459" @default.
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- W3128567057 abstract "The purpose of a clinical assessment program for electronic nicotine delivery products (ENDPs) is to demonstrate that ENDPs have the potential to reduce the risk and harm caused by cigarette smoking. To achieve this objective, ENDPs should be acceptable alternatives to cigarettes for current smokers. Therefore, ENDP use should lead to a nicotine absorption profile that resembles that of cigarettes. This can be assessed in pharmacokinetics studies that also provide additional insights into the acceptability of ENDPs. Second, ENDPs should reduce the risk of smoking-related disease. Therefore, switching from cigarette smoking to ENDP use must lead to a reduction in toxicant exposure approaching that following smoking abstinence. This can be assessed in reduced exposure studies conducted with smokers who have either switched to an ENDP or abstained from smoking. This reduction in toxicant exposure should lead to positive changes in biomarkers of potential harm (BoPHs), which can be assessed in exposure response studies. The data obtained from a clinical assessment program should provide evidence that switching from cigarette smoking to ENDP use leads not only to a reduction in toxicant exposure approaching that following smoking abstinence but also to positive changes in BoPHs. The data should also provide early insights into product acceptance and use behavior, which should be further examined by dedicated behavioral studies. This chapter will use the clinical ENDP assessment program developed by Philip Morris International as an example." @default.
- W3128567057 created "2021-02-15" @default.
- W3128567057 creator A5012278670 @default.
- W3128567057 creator A5013328989 @default.
- W3128567057 creator A5015073868 @default.
- W3128567057 creator A5048923026 @default.
- W3128567057 date "2021-01-01" @default.
- W3128567057 modified "2023-09-23" @default.
- W3128567057 title "Clinical Assessment of ENDPs" @default.
- W3128567057 cites W10305632 @default.
- W3128567057 cites W1543746024 @default.
- W3128567057 cites W1565781445 @default.
- W3128567057 cites W1801981734 @default.
- W3128567057 cites W1965692204 @default.
- W3128567057 cites W1966742492 @default.
- W3128567057 cites W1966803695 @default.
- W3128567057 cites W1967987405 @default.
- W3128567057 cites W1971596397 @default.
- W3128567057 cites W1972199176 @default.
- W3128567057 cites W1975414280 @default.
- W3128567057 cites W1975530371 @default.
- W3128567057 cites W1977617403 @default.
- W3128567057 cites W1978962137 @default.
- W3128567057 cites W1979468645 @default.
- W3128567057 cites W1981022177 @default.
- W3128567057 cites W1983882432 @default.
- W3128567057 cites W1986602349 @default.
- W3128567057 cites W1988633497 @default.
- W3128567057 cites W1996264650 @default.
- W3128567057 cites W1997871863 @default.
- W3128567057 cites W1998056438 @default.
- W3128567057 cites W1999647730 @default.
- W3128567057 cites W2001152174 @default.
- W3128567057 cites W2002778671 @default.
- W3128567057 cites W2005069726 @default.
- W3128567057 cites W2007690438 @default.
- W3128567057 cites W2009576291 @default.
- W3128567057 cites W2011711268 @default.
- W3128567057 cites W2014327575 @default.
- W3128567057 cites W2015234747 @default.
- W3128567057 cites W2018883841 @default.
- W3128567057 cites W2021089766 @default.
- W3128567057 cites W2021287314 @default.
- W3128567057 cites W2027105619 @default.
- W3128567057 cites W2029781096 @default.
- W3128567057 cites W2030471578 @default.
- W3128567057 cites W2031576215 @default.
- W3128567057 cites W2031972699 @default.
- W3128567057 cites W2039460330 @default.
- W3128567057 cites W2045139779 @default.
- W3128567057 cites W2045213593 @default.
- W3128567057 cites W2049569371 @default.
- W3128567057 cites W2049901733 @default.
- W3128567057 cites W2052693358 @default.
- W3128567057 cites W2053616905 @default.
- W3128567057 cites W2054253150 @default.
- W3128567057 cites W2054649120 @default.
- W3128567057 cites W2059571803 @default.
- W3128567057 cites W2061397591 @default.
- W3128567057 cites W2065583709 @default.
- W3128567057 cites W2066193909 @default.
- W3128567057 cites W2069074820 @default.
- W3128567057 cites W2074975199 @default.
- W3128567057 cites W2076410053 @default.
- W3128567057 cites W2082783124 @default.
- W3128567057 cites W2085174379 @default.
- W3128567057 cites W2087827648 @default.
- W3128567057 cites W2087882379 @default.
- W3128567057 cites W2088051535 @default.
- W3128567057 cites W2089177070 @default.
- W3128567057 cites W2096533285 @default.
- W3128567057 cites W2099970296 @default.
- W3128567057 cites W2102956763 @default.
- W3128567057 cites W2106796593 @default.
- W3128567057 cites W2109224187 @default.
- W3128567057 cites W2109698138 @default.
- W3128567057 cites W2110569081 @default.
- W3128567057 cites W2113307061 @default.
- W3128567057 cites W2114311055 @default.
- W3128567057 cites W2114345365 @default.
- W3128567057 cites W2114549745 @default.
- W3128567057 cites W2116438644 @default.
- W3128567057 cites W2117449697 @default.
- W3128567057 cites W2125096607 @default.
- W3128567057 cites W2127171611 @default.
- W3128567057 cites W2127363280 @default.
- W3128567057 cites W2131398405 @default.
- W3128567057 cites W2133685977 @default.
- W3128567057 cites W2134552151 @default.
- W3128567057 cites W2140459664 @default.
- W3128567057 cites W2149979963 @default.
- W3128567057 cites W2150974428 @default.
- W3128567057 cites W2152429112 @default.
- W3128567057 cites W2153252164 @default.
- W3128567057 cites W2154084998 @default.
- W3128567057 cites W2154846778 @default.
- W3128567057 cites W2155200622 @default.
- W3128567057 cites W2155519999 @default.