Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128590967> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3128590967 abstract "Differential analysis of gene-level expression is a commonly used approach for identifying disease-associated genes. Recently, intron retention (IR) has been shown to be associated with complex diseases such as cancers. IR provides value that is complementary to traditional gene-level expression. However, a systematic method to exploit IR for identifying disease-associated genes remains largely unexplored. We developed a pipeline to identify the disease-associated gene based on differential intron retention (IRDAG), which integrates IR events detected by two methods, IRFinder and iREAD. We applied it to Alzheimer’s disease (AD). We found that many of the differential genes detected based on IR were not able to be discovered by the traditional gene-level differential expression method, suggesting that our method is complementary to traditional methods. We showed that the differential genes identified with IRDAG were functionally related to AD based on the analysis of protein-protein interaction networks and brain-specific functional gene networks. Being complementary to the existing method, IRDAG provides a new and generic approach for identifying the disease-associated gene." @default.
- W3128590967 created "2021-02-15" @default.
- W3128590967 creator A5061507436 @default.
- W3128590967 creator A5064339318 @default.
- W3128590967 creator A5077611132 @default.
- W3128590967 date "2020-12-16" @default.
- W3128590967 modified "2023-09-27" @default.
- W3128590967 title "Identification of Disease-Associated Genes Based on Differential Intron Retention" @default.
- W3128590967 cites W2017079501 @default.
- W3128590967 cites W2035618305 @default.
- W3128590967 cites W2037442572 @default.
- W3128590967 cites W2090485842 @default.
- W3128590967 cites W2114104545 @default.
- W3128590967 cites W2119412782 @default.
- W3128590967 cites W2169456326 @default.
- W3128590967 cites W2410359281 @default.
- W3128590967 cites W2602408874 @default.
- W3128590967 cites W2612976808 @default.
- W3128590967 cites W2738242988 @default.
- W3128590967 cites W2783582599 @default.
- W3128590967 cites W2810189327 @default.
- W3128590967 cites W2891382651 @default.
- W3128590967 cites W2893655504 @default.
- W3128590967 cites W2894276058 @default.
- W3128590967 cites W2901303766 @default.
- W3128590967 cites W2904829642 @default.
- W3128590967 cites W2912165492 @default.
- W3128590967 cites W2921856972 @default.
- W3128590967 cites W2934961672 @default.
- W3128590967 cites W2974960552 @default.
- W3128590967 cites W3007694665 @default.
- W3128590967 cites W3105992022 @default.
- W3128590967 doi "https://doi.org/10.1109/bibm49941.2020.9313318" @default.
- W3128590967 hasPublicationYear "2020" @default.
- W3128590967 type Work @default.
- W3128590967 sameAs 3128590967 @default.
- W3128590967 citedByCount "1" @default.
- W3128590967 countsByYear W31285909672023 @default.
- W3128590967 crossrefType "proceedings-article" @default.
- W3128590967 hasAuthorship W3128590967A5061507436 @default.
- W3128590967 hasAuthorship W3128590967A5064339318 @default.
- W3128590967 hasAuthorship W3128590967A5077611132 @default.
- W3128590967 hasConcept C104317684 @default.
- W3128590967 hasConcept C116834253 @default.
- W3128590967 hasConcept C142724271 @default.
- W3128590967 hasConcept C2779134260 @default.
- W3128590967 hasConcept C41008148 @default.
- W3128590967 hasConcept C54355233 @default.
- W3128590967 hasConcept C59822182 @default.
- W3128590967 hasConcept C70721500 @default.
- W3128590967 hasConcept C71924100 @default.
- W3128590967 hasConcept C86803240 @default.
- W3128590967 hasConcept C94671646 @default.
- W3128590967 hasConceptScore W3128590967C104317684 @default.
- W3128590967 hasConceptScore W3128590967C116834253 @default.
- W3128590967 hasConceptScore W3128590967C142724271 @default.
- W3128590967 hasConceptScore W3128590967C2779134260 @default.
- W3128590967 hasConceptScore W3128590967C41008148 @default.
- W3128590967 hasConceptScore W3128590967C54355233 @default.
- W3128590967 hasConceptScore W3128590967C59822182 @default.
- W3128590967 hasConceptScore W3128590967C70721500 @default.
- W3128590967 hasConceptScore W3128590967C71924100 @default.
- W3128590967 hasConceptScore W3128590967C86803240 @default.
- W3128590967 hasConceptScore W3128590967C94671646 @default.
- W3128590967 hasLocation W31285909671 @default.
- W3128590967 hasOpenAccess W3128590967 @default.
- W3128590967 hasPrimaryLocation W31285909671 @default.
- W3128590967 hasRelatedWork W1996012994 @default.
- W3128590967 hasRelatedWork W2039352533 @default.
- W3128590967 hasRelatedWork W2041335525 @default.
- W3128590967 hasRelatedWork W2054641857 @default.
- W3128590967 hasRelatedWork W2081600652 @default.
- W3128590967 hasRelatedWork W2085341134 @default.
- W3128590967 hasRelatedWork W2092554027 @default.
- W3128590967 hasRelatedWork W2109717569 @default.
- W3128590967 hasRelatedWork W2376186192 @default.
- W3128590967 hasRelatedWork W2418488235 @default.
- W3128590967 isParatext "false" @default.
- W3128590967 isRetracted "false" @default.
- W3128590967 magId "3128590967" @default.
- W3128590967 workType "article" @default.