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• W3128595122 abstract "Polyketide synthase 13 (Pks13) is an important enzyme found in Mycobacterium tuberculosis that condenses two fatty acyl chains to produce α-alkyl β-ketoesters, which in turn serve as the precursors for the synthesis of mycolic acids that are essential building blocks for maintaining the cell wall integrity of M. tuberculosis . Coumestan derivatives have recently been identified in our group as a new chemotype that exerts its antitubercular effects via targeting of Pks13." @default.
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• W3128595122 date "2021-04-19" @default.
• W3128595122 modified "2023-10-18" @default.
• W3128595122 title "Therapeutic Potential of Coumestan Pks13 Inhibitors for Tuberculosis" @default.
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• W3128595122 doi "https://doi.org/10.1128/aac.02190-20" @default.
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