Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128596128> ?p ?o ?g. }
- W3128596128 endingPage "198" @default.
- W3128596128 startingPage "187" @default.
- W3128596128 abstract "Understanding the cellular underpinnings of neurodegeneration remains a challenge; loss of synapses and dendritic arborization are characteristic and can be quantified in vivo, with [11C]UCB-J PET and MRI-based Orientation Dispersion Imaging (ODI), respectively. We aimed to assess how both measures are correlated, in 4R-tauopathies of progressive supranuclear palsy - Richardson's Syndrome (PSP-RS; n = 22) and amyloid-negative (determined by [11C]PiB PET) Corticobasal Syndrome (Cortiobasal degeneration, CBD; n =14), as neurodegenerative disease models, in this proof-of-concept study. Compared to controls (n = 27), PSP-RS and CBD patients had widespread reductions in cortical ODI, and [11C]UCB-J non-displaceable binding potential (BPND) in excess of atrophy. In PSP-RS and CBD separately, regional cortical ODI was significantly associated with [11C]UCB-J BPND in disease-associated regions (p < 0.05, FDR corrected). Our findings indicate that reductions in synaptic density and dendritic complexity in PSP-RS and CBD are more severe and extensive than atrophy. Furthermore, both measures are tightly coupled in vivo, furthering our understanding of the pathophysiology of neurodegeneration, and applicable to studies of early neurodegeneration with a safe and widely available MRI platform." @default.
- W3128596128 created "2021-02-15" @default.
- W3128596128 creator A5003794882 @default.
- W3128596128 creator A5007616574 @default.
- W3128596128 creator A5009292765 @default.
- W3128596128 creator A5014262891 @default.
- W3128596128 creator A5014688641 @default.
- W3128596128 creator A5022468115 @default.
- W3128596128 creator A5024646528 @default.
- W3128596128 creator A5025003387 @default.
- W3128596128 creator A5031935895 @default.
- W3128596128 creator A5034431716 @default.
- W3128596128 creator A5051840780 @default.
- W3128596128 creator A5062484343 @default.
- W3128596128 creator A5062596710 @default.
- W3128596128 creator A5064571229 @default.
- W3128596128 creator A5075493660 @default.
- W3128596128 creator A5078693273 @default.
- W3128596128 creator A5079872791 @default.
- W3128596128 date "2021-05-01" @default.
- W3128596128 modified "2023-10-18" @default.
- W3128596128 title "In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies" @default.
- W3128596128 cites W1849525423 @default.
- W3128596128 cites W1850550907 @default.
- W3128596128 cites W1862190875 @default.
- W3128596128 cites W1967807254 @default.
- W3128596128 cites W1977045845 @default.
- W3128596128 cites W1989215575 @default.
- W3128596128 cites W1990752558 @default.
- W3128596128 cites W1999522048 @default.
- W3128596128 cites W2004813308 @default.
- W3128596128 cites W2007804566 @default.
- W3128596128 cites W2015897296 @default.
- W3128596128 cites W2032254014 @default.
- W3128596128 cites W2032687897 @default.
- W3128596128 cites W2041390299 @default.
- W3128596128 cites W2042938421 @default.
- W3128596128 cites W2056313099 @default.
- W3128596128 cites W2057249855 @default.
- W3128596128 cites W2060010910 @default.
- W3128596128 cites W2062340864 @default.
- W3128596128 cites W2079499736 @default.
- W3128596128 cites W2087919208 @default.
- W3128596128 cites W2099969014 @default.
- W3128596128 cites W2100084621 @default.
- W3128596128 cites W2101473364 @default.
- W3128596128 cites W2124538980 @default.
- W3128596128 cites W2125077747 @default.
- W3128596128 cites W2126693856 @default.
- W3128596128 cites W2136557657 @default.
- W3128596128 cites W2137779895 @default.
- W3128596128 cites W2144707045 @default.
- W3128596128 cites W2147637831 @default.
- W3128596128 cites W2156326104 @default.
- W3128596128 cites W2168844688 @default.
- W3128596128 cites W2176311229 @default.
- W3128596128 cites W2178916357 @default.
- W3128596128 cites W2185034389 @default.
- W3128596128 cites W2206024306 @default.
- W3128596128 cites W2334692654 @default.
- W3128596128 cites W2470259419 @default.
- W3128596128 cites W2503767557 @default.
- W3128596128 cites W2525041896 @default.
- W3128596128 cites W2529649944 @default.
- W3128596128 cites W2561810854 @default.
- W3128596128 cites W2607969057 @default.
- W3128596128 cites W2610402968 @default.
- W3128596128 cites W2623663856 @default.
- W3128596128 cites W2742230759 @default.
- W3128596128 cites W2747366609 @default.
- W3128596128 cites W2765999949 @default.
- W3128596128 cites W2766289228 @default.
- W3128596128 cites W2791084533 @default.
- W3128596128 cites W2792229831 @default.
- W3128596128 cites W2794699203 @default.
- W3128596128 cites W2803816323 @default.
- W3128596128 cites W2804251845 @default.
- W3128596128 cites W2883456549 @default.
- W3128596128 cites W2883737562 @default.
- W3128596128 cites W2887203046 @default.
- W3128596128 cites W2912593758 @default.
- W3128596128 cites W2950571742 @default.
- W3128596128 cites W2968327236 @default.
- W3128596128 cites W2979263588 @default.
- W3128596128 cites W2995601552 @default.
- W3128596128 cites W3022376055 @default.
- W3128596128 cites W3025834426 @default.
- W3128596128 cites W3040935827 @default.
- W3128596128 cites W3108978982 @default.
- W3128596128 cites W622376569 @default.
- W3128596128 cites W90630876 @default.
- W3128596128 doi "https://doi.org/10.1016/j.neurobiolaging.2021.01.016" @default.
- W3128596128 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8209289" @default.
- W3128596128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33631470" @default.
- W3128596128 hasPublicationYear "2021" @default.
- W3128596128 type Work @default.
- W3128596128 sameAs 3128596128 @default.
- W3128596128 citedByCount "10" @default.