FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128613344> ?p ?o ?g. }

• W3128613344 endingPage "599" @default.
• W3128613344 startingPage "588" @default.
• W3128613344 abstract "NOD-like receptor protein 3 (NLRP3) promotes the inflammatory response during progression of nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH). This study aimed to further delineate the role of NLRP3 in NASH development by abolishing its expression in mice. A high-fat and calorie diet plus high fructose and glucose in drinking water (HFCD-HF/G) was used to establish NASH in both wild-type (WT) and NLRP3 knock-out (KO) mice. Hepatocellular injury, hepatic steatosis and fibrosis, as well as inflammatory response and insulin resistance in the liver and epidydimal white adipose tissue (eWAT) were determined. Elevated body weight, liver weight and serum alanine transaminase level, increased hepatic triglyceride accumulation and collagen deposition, and worsened systemic insulin resistance were observed in Nlrp3−/− mice compared to WT mice under HFCD-HF/G feeding. Upregulated hepatic transcription of tumor necrosis factor-α (TNF-α) and monocyte chemotactic protein-1 (MCP-1), and enhanced infiltration of inducible nitric oxide synthase-positive (iNOS+) M1 macrophages were also documented in HFCD-HF/G-fed Nlrp3−/− mice in comparison to HFCD-HF/G-fed WT mice. Moreover, transcription of TNF-α and MCP-1 and infiltration of iNOS+ M1 macrophages were increased in the liver of Nlrp3−/− mice under control diet. NLRP3 deficiency did not attenuate, but instead aggravated NASH development under HFCD-HF/G feeding. The worsened extent of NASH might be attributed to enhanced hepatic MCP-1 expression and M1 macrophage infiltration in Nlrp3−/− mice. Our study points to additional caution when NLRP3 blockade is considered as a therapeutic strategy in the treatment of human NASH." @default.
• W3128613344 created "2021-02-15" @default.
• W3128613344 creator A5004717192 @default.
• W3128613344 creator A5029029373 @default.
• W3128613344 creator A5073686280 @default.
• W3128613344 creator A5079625906 @default.
• W3128613344 creator A5091482274 @default.
• W3128613344 date "2021-05-01" @default.
• W3128613344 modified "2023-10-03" @default.
• W3128613344 title "NLRP3 deficiency did not attenuate NASH development under high fat calorie diet plus high fructose and glucose in drinking water" @default.
• W3128613344 cites W1529674879 @default.
• W3128613344 cites W1559677484 @default.
• W3128613344 cites W1776128289 @default.
• W3128613344 cites W1927491384 @default.
• W3128613344 cites W1967972402 @default.
• W3128613344 cites W1972749969 @default.
• W3128613344 cites W1977508200 @default.
• W3128613344 cites W2013907285 @default.
• W3128613344 cites W2045675139 @default.
• W3128613344 cites W2065653369 @default.
• W3128613344 cites W2067740038 @default.
• W3128613344 cites W2079893663 @default.
• W3128613344 cites W2085170886 @default.
• W3128613344 cites W2098000380 @default.
• W3128613344 cites W2136481995 @default.
• W3128613344 cites W2144275312 @default.
• W3128613344 cites W2150702412 @default.
• W3128613344 cites W2171752155 @default.
• W3128613344 cites W2204688218 @default.
• W3128613344 cites W2320838224 @default.
• W3128613344 cites W2332784463 @default.
• W3128613344 cites W2515192347 @default.
• W3128613344 cites W2582393724 @default.
• W3128613344 cites W2585046292 @default.
• W3128613344 cites W2590236540 @default.
• W3128613344 cites W2596317107 @default.
• W3128613344 cites W2599090616 @default.
• W3128613344 cites W2599822883 @default.
• W3128613344 cites W2606513998 @default.
• W3128613344 cites W2724425486 @default.
• W3128613344 cites W2730470503 @default.
• W3128613344 cites W2742678051 @default.
• W3128613344 cites W2754155267 @default.
• W3128613344 cites W2757837983 @default.
• W3128613344 cites W2757958974 @default.
• W3128613344 cites W2760098333 @default.
• W3128613344 cites W2770129291 @default.
• W3128613344 cites W2783618610 @default.
• W3128613344 cites W2801929531 @default.
• W3128613344 cites W2810603736 @default.
• W3128613344 cites W2902538813 @default.
• W3128613344 cites W2914406945 @default.
• W3128613344 cites W2961112538 @default.
• W3128613344 cites W2972086206 @default.
• W3128613344 cites W2977362851 @default.
• W3128613344 cites W2987834214 @default.
• W3128613344 cites W2999533459 @default.
• W3128613344 cites W3012020751 @default.
• W3128613344 cites W3047392456 @default.
• W3128613344 cites W4211217520 @default.
• W3128613344 cites W56957918 @default.
• W3128613344 doi "https://doi.org/10.1038/s41374-021-00535-3" @default.
• W3128613344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33526807" @default.
• W3128613344 hasPublicationYear "2021" @default.
• W3128613344 type Work @default.
• W3128613344 sameAs 3128613344 @default.
• W3128613344 citedByCount "6" @default.
• W3128613344 countsByYear W31286133442021 @default.
• W3128613344 countsByYear W31286133442022 @default.
• W3128613344 countsByYear W31286133442023 @default.
• W3128613344 crossrefType "journal-article" @default.
• W3128613344 hasAuthorship W3128613344A5004717192 @default.
• W3128613344 hasAuthorship W3128613344A5029029373 @default.
• W3128613344 hasAuthorship W3128613344A5073686280 @default.
• W3128613344 hasAuthorship W3128613344A5079625906 @default.
• W3128613344 hasAuthorship W3128613344A5091482274 @default.
• W3128613344 hasBestOaLocation W31286133441 @default.
• W3128613344 hasConcept C126322002 @default.
• W3128613344 hasConcept C134018914 @default.
• W3128613344 hasConcept C171089720 @default.
• W3128613344 hasConcept C185592680 @default.
• W3128613344 hasConcept C2776175330 @default.
• W3128613344 hasConcept C2776637226 @default.
• W3128613344 hasConcept C2777391703 @default.
• W3128613344 hasConcept C2778772119 @default.
• W3128613344 hasConcept C2779134260 @default.
• W3128613344 hasConcept C2779306644 @default.
• W3128613344 hasConcept C2779478299 @default.
• W3128613344 hasConcept C2780559512 @default.
• W3128613344 hasConcept C71924100 @default.
• W3128613344 hasConceptScore W3128613344C126322002 @default.
• W3128613344 hasConceptScore W3128613344C134018914 @default.
• W3128613344 hasConceptScore W3128613344C171089720 @default.
• W3128613344 hasConceptScore W3128613344C185592680 @default.
• W3128613344 hasConceptScore W3128613344C2776175330 @default.
• W3128613344 hasConceptScore W3128613344C2776637226 @default.
• W3128613344 hasConceptScore W3128613344C2777391703 @default.
• W3128613344 hasConceptScore W3128613344C2778772119 @default.

• next