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- W3128640356 abstract "In 1925, Austrian ophthalmologist Maximilian Salzmann reported on a nodular degeneration secondary to phlyctenular or trachomatous keratitis. Salzmann nodular degeneration (SND) was later redefined as a noninflammatory, indolent, degenerative condition associated with the formation of fibrous outgrowth resulting in nodules in any part of the cornea, commonly involving peri peripheral to peripheral areas.Nodule formation is most commonly idiopathic but has been associated with inflammation, trauma, and surgery. SND is rare, most often occurring in the fifth decade of life, though it may range from 4 to 90 years. Most cases are bilateral. It predominantly affects women and may affect Whites more often. Spontaneous remission is unlikely, but symptoms typically improve with lubrication and topical anti-inflammatory therapy. Surgical options in refractory cases include manual excision, phototherapeutic keratectomy (PTK) with or without the use of topical mitomycin-C, and lamellar or penetrating keratoplasty. Though many patients are asymptomatic, SND may cause significant morbidity and contribute to the degradation of vision. Prognosis is generally good; however, recognition and treatment of SND and its underlying factors are essential as no cases of spontaneous remission have been reported." @default.
- W3128640356 created "2021-02-15" @default.
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- W3128640356 date "2020-01-01" @default.
- W3128640356 modified "2023-09-23" @default.
- W3128640356 title "Salzmanns Nodular Corneal Degeneration" @default.
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