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- W3128647488 endingPage "111313" @default.
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- W3128647488 abstract "The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a challenge to global health. At present, many candidate small-molecule therapeutics have been developed that can inhibit both the infection and replication of SARS-CoV-2 and even potentially relieve cytokine storms and other related complications. Meanwhile, host-targeted drugs that inhibit cellular transmembrane serine protease (TMPRSS2) can prevent SARS-CoV-2 from entering cells, and its combination with chloroquine and dihydroorotate dehydrogenase (DHODH) inhibitors can limit the spread of SARS-CoV-2 and reduce the morbidity and mortality of patients with COVID-19. The present article provides an overview of these small-molecule therapeutics based on insights from medicinal chemistry research and focuses on RNA-dependent RNA polymerase (RdRp) inhibitors, such as the nucleoside analogues remdesivir, favipiravir and ribavirin. This review also covers inhibitors of 3C-like protease (3CLpro), papain-like protease (PLpro) and other potentially innovative active ingredient molecules, describing their potential targets, activities, clinical status and side effects." @default.
- W3128647488 created "2021-02-15" @default.
- W3128647488 creator A5001215875 @default.
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- W3128647488 creator A5089547861 @default.
- W3128647488 date "2021-05-01" @default.
- W3128647488 modified "2023-09-27" @default.
- W3128647488 title "An update review of emerging small-molecule therapeutic options for COVID-19" @default.
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