Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128661142> ?p ?o ?g. }
- W3128661142 endingPage "e568" @default.
- W3128661142 startingPage "e559" @default.
- W3128661142 abstract "Allogeneic hematopoietic cell transplantation (HCT) outcomes may be predicted by published risk scores; however, the ideal system has not been identified for acute leukemias.We retrospectively examined the Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI), modified European Group for Blood and Marrow Transplantation (mEBMT), EBMT-Alternating Decision Tree (ADT), and others on 231 patients with acute leukemia.Acute myeloid leukemia was diagnosed in 200 patients, and acute lymphocytic leukemia was diagnosed in 31 patients. For HCT-CI, patients were grouped as 0 to 1, 2 to 3, and > 3. For mEBMT, patients were grouped as 0 to 2, 3, and > 3. For EBMT-ADT, the 100-day mortality was calculated and grouped as ≤ 4.1%, 4.1% to 11.5%, and > 11.5%. Higher HCI-CI demonstrated inferior overall survival (P = .04; c-statistic, 0.57), whereas mEBMT and EBMT-ADT did not stratify well. A new weighted score was developed that assigned 1 point for age ≥ 60 years, acute lymphocytic leukemia diagnosis, mismatch unrelated or haploidentical donor, cardiovascular comorbidity, and pre-transplant diabetes, whereas arrhythmia received 2 points. The new weighted score assigned 0 points to 88 (38%), 1 to 2 points to 121 (52%) and ≥ 3 points to 22 (10%) patients, and demonstrated improved prognostic capability compared with the other scores (P = .0001; c-statistic, 0.61).The HCT-CI stratifies patients with leukemia for overall survival but is inferior to our single-center score, which is influenced by cardiac comorbidity and arrhythmia. Differences in pre-transplant risk scores may be related to different transplant practices." @default.
- W3128661142 created "2021-02-15" @default.
- W3128661142 creator A5003519204 @default.
- W3128661142 creator A5014346242 @default.
- W3128661142 creator A5015894671 @default.
- W3128661142 creator A5017586094 @default.
- W3128661142 creator A5038048073 @default.
- W3128661142 creator A5040159118 @default.
- W3128661142 creator A5049111943 @default.
- W3128661142 creator A5051261755 @default.
- W3128661142 creator A5051893307 @default.
- W3128661142 creator A5071646305 @default.
- W3128661142 creator A5072952978 @default.
- W3128661142 creator A5073179735 @default.
- W3128661142 creator A5080055664 @default.
- W3128661142 creator A5084708084 @default.
- W3128661142 date "2021-06-01" @default.
- W3128661142 modified "2023-10-13" @default.
- W3128661142 title "Comparison of the Prognostic Ability of the HCT-CI, the Modified EBMT, and the EBMT-ADT Pre-transplant Risk Scores for Acute Leukemia" @default.
- W3128661142 cites W1917062437 @default.
- W3128661142 cites W1966970729 @default.
- W3128661142 cites W1967031189 @default.
- W3128661142 cites W1973665333 @default.
- W3128661142 cites W1983593884 @default.
- W3128661142 cites W1997027018 @default.
- W3128661142 cites W1999830441 @default.
- W3128661142 cites W2000445173 @default.
- W3128661142 cites W2005670480 @default.
- W3128661142 cites W2025358933 @default.
- W3128661142 cites W2032053073 @default.
- W3128661142 cites W2049733896 @default.
- W3128661142 cites W2057807351 @default.
- W3128661142 cites W2064085613 @default.
- W3128661142 cites W2072682306 @default.
- W3128661142 cites W2073081174 @default.
- W3128661142 cites W2075776062 @default.
- W3128661142 cites W2076744639 @default.
- W3128661142 cites W2101846955 @default.
- W3128661142 cites W2109081248 @default.
- W3128661142 cites W2109906075 @default.
- W3128661142 cites W2111817119 @default.
- W3128661142 cites W2117550229 @default.
- W3128661142 cites W2120756704 @default.
- W3128661142 cites W2128812336 @default.
- W3128661142 cites W2129925362 @default.
- W3128661142 cites W2133048986 @default.
- W3128661142 cites W2149407433 @default.
- W3128661142 cites W2152197116 @default.
- W3128661142 cites W2274486363 @default.
- W3128661142 cites W2586322360 @default.
- W3128661142 cites W2768941569 @default.
- W3128661142 cites W2884698784 @default.
- W3128661142 cites W2904467774 @default.
- W3128661142 cites W2950244989 @default.
- W3128661142 doi "https://doi.org/10.1016/j.clml.2021.01.022" @default.
- W3128661142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33678592" @default.
- W3128661142 hasPublicationYear "2021" @default.
- W3128661142 type Work @default.
- W3128661142 sameAs 3128661142 @default.
- W3128661142 citedByCount "3" @default.
- W3128661142 countsByYear W31286611422022 @default.
- W3128661142 crossrefType "journal-article" @default.
- W3128661142 hasAuthorship W3128661142A5003519204 @default.
- W3128661142 hasAuthorship W3128661142A5014346242 @default.
- W3128661142 hasAuthorship W3128661142A5015894671 @default.
- W3128661142 hasAuthorship W3128661142A5017586094 @default.
- W3128661142 hasAuthorship W3128661142A5038048073 @default.
- W3128661142 hasAuthorship W3128661142A5040159118 @default.
- W3128661142 hasAuthorship W3128661142A5049111943 @default.
- W3128661142 hasAuthorship W3128661142A5051261755 @default.
- W3128661142 hasAuthorship W3128661142A5051893307 @default.
- W3128661142 hasAuthorship W3128661142A5071646305 @default.
- W3128661142 hasAuthorship W3128661142A5072952978 @default.
- W3128661142 hasAuthorship W3128661142A5073179735 @default.
- W3128661142 hasAuthorship W3128661142A5080055664 @default.
- W3128661142 hasAuthorship W3128661142A5084708084 @default.
- W3128661142 hasConcept C126322002 @default.
- W3128661142 hasConcept C143998085 @default.
- W3128661142 hasConcept C2776863199 @default.
- W3128661142 hasConcept C2777408962 @default.
- W3128661142 hasConcept C2778461978 @default.
- W3128661142 hasConcept C2778729363 @default.
- W3128661142 hasConcept C2779159551 @default.
- W3128661142 hasConcept C2911091166 @default.
- W3128661142 hasConcept C71924100 @default.
- W3128661142 hasConceptScore W3128661142C126322002 @default.
- W3128661142 hasConceptScore W3128661142C143998085 @default.
- W3128661142 hasConceptScore W3128661142C2776863199 @default.
- W3128661142 hasConceptScore W3128661142C2777408962 @default.
- W3128661142 hasConceptScore W3128661142C2778461978 @default.
- W3128661142 hasConceptScore W3128661142C2778729363 @default.
- W3128661142 hasConceptScore W3128661142C2779159551 @default.
- W3128661142 hasConceptScore W3128661142C2911091166 @default.
- W3128661142 hasConceptScore W3128661142C71924100 @default.
- W3128661142 hasIssue "6" @default.
- W3128661142 hasLocation W31286611421 @default.
- W3128661142 hasLocation W31286611422 @default.
- W3128661142 hasOpenAccess W3128661142 @default.