FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128661917> ?p ?o ?g. }

• W3128661917 abstract "Head and neck cancers (HNCs) rank as the sixth common and the seventh leading cause of cancer-related death worldwide, with an estimated incidence of 600,000 cases and 40–50% mortality rate every year. Radiotherapy is a common local therapeutic modality for HNC mainly through the function of ionizing radiation, with approximately 60% of patients treated with radiotherapy or chemoradiotherapy. Although radiotherapy is more advanced and widely used in clinical practice, the 5-year overall survival rates of locally advanced HNCs are still less than 40%. HNC cell resistance to radiotherapy remains one of the major challenges to improve the overall survival in HNC patients. Non-coding RNAs (ncRNAs) are newly discovered functional small RNA molecules that are different from messenger RNAs, which can be translated into a protein. Many previous studies have reported the dysregulation and function of ncRNAs in HNC. Importantly, researchers reported that several ncRNAs were also dysregulated in radiotherapy-sensitive or radiotherapy-resistant HNC tissues compared with the normal cancer tissues. They found that ectopically elevating or knocking down expression of some ncRNAs could significantly influence the response of HNC cancer cells to radiotherapy, indicating that ncRNAs could regulate the sensitivity of cancer cells to radiotherapy. The implying mechanism for ncRNAs in regulating radiotherapy sensitivity may be due to its roles on affecting DNA damage sensation, inducing cell cycle arrest, regulating DNA damage repair, modulating cell apoptosis, etc. Additionally, clinical studies reported that in situ ncRNA expression in HNC tissues may predict the response of radiotherapy, and circulating ncRNA from body liquid serves as minimally invasive therapy-responsive and prognostic biomarkers in HNC. In this review, we aimed to summarize the current function and mechanism of ncRNAs in regulating the sensitivity of HNC cancer cells to radiotherapy and comprehensively described the state of the art on the role of ncRNAs in the prognosis prediction, therapy monitoring, and prediction of response to radiotherapy in HNC." @default.
• W3128661917 created "2021-02-15" @default.
• W3128661917 creator A5023691773 @default.
• W3128661917 creator A5052198356 @default.
• W3128661917 date "2021-02-11" @default.
• W3128661917 modified "2023-10-03" @default.
• W3128661917 title "Role of Non-coding RNAs on the Radiotherapy Sensitivity and Resistance of Head and Neck Cancer: From Basic Research to Clinical Application" @default.
• W3128661917 cites W1583840873 @default.
• W3128661917 cites W1604123373 @default.
• W3128661917 cites W1721180843 @default.
• W3128661917 cites W1757407923 @default.
• W3128661917 cites W1871976549 @default.
• W3128661917 cites W1904804536 @default.
• W3128661917 cites W1924630281 @default.
• W3128661917 cites W1942614232 @default.
• W3128661917 cites W1989790041 @default.
• W3128661917 cites W1990365150 @default.
• W3128661917 cites W2007817463 @default.
• W3128661917 cites W2017729786 @default.
• W3128661917 cites W2019219567 @default.
• W3128661917 cites W2025402420 @default.
• W3128661917 cites W2049108649 @default.
• W3128661917 cites W2061197983 @default.
• W3128661917 cites W2074879777 @default.
• W3128661917 cites W2089257078 @default.
• W3128661917 cites W2108792373 @default.
• W3128661917 cites W2115093090 @default.
• W3128661917 cites W2118385360 @default.
• W3128661917 cites W2119306093 @default.
• W3128661917 cites W2121298850 @default.
• W3128661917 cites W2124050695 @default.
• W3128661917 cites W2124684616 @default.
• W3128661917 cites W2130146081 @default.
• W3128661917 cites W2130883309 @default.
• W3128661917 cites W2131978108 @default.
• W3128661917 cites W2135591542 @default.
• W3128661917 cites W2136542410 @default.
• W3128661917 cites W2136922347 @default.
• W3128661917 cites W2161320250 @default.
• W3128661917 cites W2173172085 @default.
• W3128661917 cites W2184889525 @default.
• W3128661917 cites W2214655721 @default.
• W3128661917 cites W2276492661 @default.
• W3128661917 cites W2284415752 @default.
• W3128661917 cites W2346875448 @default.
• W3128661917 cites W2415352639 @default.
• W3128661917 cites W2462901000 @default.
• W3128661917 cites W2568514523 @default.
• W3128661917 cites W2589283006 @default.
• W3128661917 cites W2600309583 @default.
• W3128661917 cites W2606660292 @default.
• W3128661917 cites W2620322469 @default.
• W3128661917 cites W2621719395 @default.
• W3128661917 cites W2625283862 @default.
• W3128661917 cites W2735502693 @default.
• W3128661917 cites W2753941672 @default.
• W3128661917 cites W2761904316 @default.
• W3128661917 cites W2766638837 @default.
• W3128661917 cites W2789358942 @default.
• W3128661917 cites W2793226176 @default.
• W3128661917 cites W2793598720 @default.
• W3128661917 cites W2793831471 @default.
• W3128661917 cites W2794341248 @default.
• W3128661917 cites W2810503019 @default.
• W3128661917 cites W2903461327 @default.
• W3128661917 cites W2908777854 @default.
• W3128661917 cites W2918122045 @default.
• W3128661917 cites W2924983009 @default.
• W3128661917 cites W2929661915 @default.
• W3128661917 cites W2936304341 @default.
• W3128661917 cites W2944296806 @default.
• W3128661917 cites W2963434743 @default.
• W3128661917 cites W2963440793 @default.
• W3128661917 cites W2969456125 @default.
• W3128661917 cites W2998513811 @default.
• W3128661917 cites W3000271060 @default.
• W3128661917 cites W3021039989 @default.
• W3128661917 cites W3021854159 @default.
• W3128661917 cites W3024034565 @default.
• W3128661917 cites W3031771443 @default.
• W3128661917 cites W3045119100 @default.
• W3128661917 cites W3049324106 @default.
• W3128661917 cites W3089669346 @default.
• W3128661917 cites W3091937817 @default.
• W3128661917 cites W3092037171 @default.
• W3128661917 cites W3092300183 @default.
• W3128661917 cites W3094325957 @default.
• W3128661917 cites W3095320513 @default.
• W3128661917 cites W3095530520 @default.
• W3128661917 cites W3095668420 @default.
• W3128661917 cites W3096139668 @default.
• W3128661917 cites W3096216564 @default.
• W3128661917 cites W3096945771 @default.
• W3128661917 cites W3100155593 @default.
• W3128661917 doi "https://doi.org/10.3389/fcell.2020.637435" @default.
• W3128661917 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7905100" @default.
• W3128661917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33644038" @default.
• W3128661917 hasPublicationYear "2021" @default.
• W3128661917 type Work @default.
• W3128661917 sameAs 3128661917 @default.

• next