Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128667890> ?p ?o ?g. }
- W3128667890 endingPage "110197" @default.
- W3128667890 startingPage "110197" @default.
- W3128667890 abstract "Nasal secretory fluid proteomes (NSPs) can provide valuable information about the physiopathology and prognosis of respiratory tract diseases. This study aimed to determine changes in NSP by using proteomics in calves treated with lipopolysaccharide (LPS) or LPS + choline. Healthy calves (n = 10) were treated with LPS (2 μg/kg/iv). Five minutes after LPS injection, the calves received a second iv injection with saline (n = 5, LPS + saline group) or saline containing 1 mg/kg choline (n = 5, LPS + choline group). Nasal secretions were collected before (baseline), at 1 h and 24 h after the treatments and analysed using label-free liquid chromatography–tandem mass spectrometry (LCMS/MS). Differentially expressed proteins (>1.2-fold-change) were identified at the different time points in each group. A total of 52 proteins were up- and 46 were downregulated at 1 h and 24 h in the LPS + saline group. The upregulated proteins that showed the highest changes after LPS administration were small ubiquitin-related modifier-3 (SUMO3) and glutathione peroxidase-1 (GPX1), whereas the most downregulated protein was E3 ubiquitin-protein ligase (TRIM17). Treatment with choline reduced the number of upregulated (32 proteins) and downregulated proteins (33 proteins) in the NSPs induced by LPS. It can be concluded that the proteome composition of nasal fluid in calves changes after LPS, reflecting different pathways, such as the activation of the immunological response, oxidative stress, ubiquitin pathway, and SUMOylation. Choline treatment alters the NSP response to LPS." @default.
- W3128667890 created "2021-02-15" @default.
- W3128667890 creator A5017340967 @default.
- W3128667890 creator A5021963150 @default.
- W3128667890 creator A5035900283 @default.
- W3128667890 creator A5038500007 @default.
- W3128667890 creator A5040815127 @default.
- W3128667890 creator A5045307508 @default.
- W3128667890 creator A5051699127 @default.
- W3128667890 creator A5053453489 @default.
- W3128667890 creator A5067279763 @default.
- W3128667890 date "2021-03-01" @default.
- W3128667890 modified "2023-10-17" @default.
- W3128667890 title "Nasal secretory protein changes following intravenous choline administration in calves with experimentally induced endotoxaemia" @default.
- W3128667890 cites W1577070562 @default.
- W3128667890 cites W1918184794 @default.
- W3128667890 cites W1969364355 @default.
- W3128667890 cites W1973637278 @default.
- W3128667890 cites W1974972293 @default.
- W3128667890 cites W1983365529 @default.
- W3128667890 cites W1990015480 @default.
- W3128667890 cites W1996267694 @default.
- W3128667890 cites W1997058261 @default.
- W3128667890 cites W2002797282 @default.
- W3128667890 cites W2009738292 @default.
- W3128667890 cites W2021741522 @default.
- W3128667890 cites W2041942794 @default.
- W3128667890 cites W2042710688 @default.
- W3128667890 cites W2043927273 @default.
- W3128667890 cites W2044891194 @default.
- W3128667890 cites W2044989255 @default.
- W3128667890 cites W2047365750 @default.
- W3128667890 cites W2056402897 @default.
- W3128667890 cites W2059934152 @default.
- W3128667890 cites W2061454248 @default.
- W3128667890 cites W2066374968 @default.
- W3128667890 cites W2078606824 @default.
- W3128667890 cites W2096041824 @default.
- W3128667890 cites W2098866603 @default.
- W3128667890 cites W2103637928 @default.
- W3128667890 cites W2117806694 @default.
- W3128667890 cites W2142137540 @default.
- W3128667890 cites W2143197595 @default.
- W3128667890 cites W2170963650 @default.
- W3128667890 cites W2321109325 @default.
- W3128667890 cites W2472819017 @default.
- W3128667890 cites W2485383922 @default.
- W3128667890 cites W2522837437 @default.
- W3128667890 cites W2530626079 @default.
- W3128667890 cites W2537845836 @default.
- W3128667890 cites W2550737778 @default.
- W3128667890 cites W2554480589 @default.
- W3128667890 cites W2556247603 @default.
- W3128667890 cites W2621370764 @default.
- W3128667890 cites W2735527928 @default.
- W3128667890 cites W2772403987 @default.
- W3128667890 cites W2778371758 @default.
- W3128667890 cites W2803857778 @default.
- W3128667890 cites W2808305854 @default.
- W3128667890 cites W2886841164 @default.
- W3128667890 cites W2887294942 @default.
- W3128667890 cites W2956654838 @default.
- W3128667890 cites W2961560531 @default.
- W3128667890 cites W2970898531 @default.
- W3128667890 cites W2972888987 @default.
- W3128667890 cites W3014995182 @default.
- W3128667890 cites W4321428162 @default.
- W3128667890 cites W59993707 @default.
- W3128667890 doi "https://doi.org/10.1016/j.vetimm.2021.110197" @default.
- W3128667890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33550189" @default.
- W3128667890 hasPublicationYear "2021" @default.
- W3128667890 type Work @default.
- W3128667890 sameAs 3128667890 @default.
- W3128667890 citedByCount "1" @default.
- W3128667890 countsByYear W31286678902023 @default.
- W3128667890 crossrefType "journal-article" @default.
- W3128667890 hasAuthorship W3128667890A5017340967 @default.
- W3128667890 hasAuthorship W3128667890A5021963150 @default.
- W3128667890 hasAuthorship W3128667890A5035900283 @default.
- W3128667890 hasAuthorship W3128667890A5038500007 @default.
- W3128667890 hasAuthorship W3128667890A5040815127 @default.
- W3128667890 hasAuthorship W3128667890A5045307508 @default.
- W3128667890 hasAuthorship W3128667890A5051699127 @default.
- W3128667890 hasAuthorship W3128667890A5053453489 @default.
- W3128667890 hasAuthorship W3128667890A5067279763 @default.
- W3128667890 hasConcept C104317684 @default.
- W3128667890 hasConcept C104397665 @default.
- W3128667890 hasConcept C105702510 @default.
- W3128667890 hasConcept C126322002 @default.
- W3128667890 hasConcept C127561419 @default.
- W3128667890 hasConcept C134018914 @default.
- W3128667890 hasConcept C153911025 @default.
- W3128667890 hasConcept C16685009 @default.
- W3128667890 hasConcept C185592680 @default.
- W3128667890 hasConcept C203014093 @default.
- W3128667890 hasConcept C2776151105 @default.
- W3128667890 hasConcept C2777397205 @default.
- W3128667890 hasConcept C2778754761 @default.