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- W3128668852 abstract "Polarity proteins are fundamental to the establishment and maintenance of breast tissue integrity, whereas alterations of their amino acid sequence and protein structure can drive breast cancer formation and progression. Scrib is a multi-functional scaffold protein whose proper localization within the cell is pivotal for its correct function. We report here that the ectopic expression of a truncated form of the polarity protein Scrib, mainly composed of the LRR domain, drives MDA-MB231 breast cancer cells to caspase 3-mediated apoptotic cell death. Furthermore, we identify the truncated Scrib as a regulator of JNK/c-Jun, Notch and Wnt/I²-catenin signalling pathways. Our results indicate that the ectopic expression of the truncated Scrib in a breast cancer cell line with a specific background of genetic mutations (KRAS, AFRGAP1, BRAF, MYCL) activates a program of intracellular molecular alterations and promotes apoptosis." @default.
- W3128668852 created "2021-02-15" @default.
- W3128668852 creator A5080203605 @default.
- W3128668852 date "2019-07-26" @default.
- W3128668852 modified "2023-10-17" @default.
- W3128668852 title "A Truncated Form of the Polarity Protein SCRIB Induces Apoptosis in MDA-MB231 Cells by Regulating Components of Several Signalling Pathways" @default.
- W3128668852 doi "https://doi.org/10.19080/ctoij.2019.14.555894" @default.
- W3128668852 hasPublicationYear "2019" @default.
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