FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128668892> ?p ?o ?g. }

• W3128668892 endingPage "168" @default.
• W3128668892 startingPage "162" @default.
• W3128668892 abstract "Folic acid (FA) affect human physiology and drug metabolism. Up to now, the effect of microgravity on the pharmacokinetics of FA remains unclear. The pharmacokinetics of FA in Sprague–Dawley (SD) rats are laying a foundation for safe medicine administration of astronauts. Proteins expression of such FA metabolic enzymes as Methyltetrahydrofolate reductase (MTHFR), Cystathionine beta synthase (CBS) and Methionine synthase (MS) in a variety of organs was analyzed with Western-Blot, and mRNA expression was detected by RT-PCR. The plasma concentration–time profile of FA in normal or tail-suspended SD rats was acquired by liquid chromatography-tandem mass spectrometry (LC-MS/MS) after oral administration of FA. Area under curve (AUC) and Cmax of FA in SD rats decreased significantly with extending period of tail-suspension. In terms of expressed level of metabolic enzymes over four suspension terms, as well as the level of the corresponding mRNAs, the following regularities were found: an obvious sharp decline of MTHFR tissue in kidney, a time-dependent increase of CBS in liver tissue and duodenum tissues, the resemblance of MS fluctuation to that of CBS in tested tissues. A four-week simulated microgravity of SD rats exhibits an unequivocal diminish of bioavailability of FA, and simulated microgravity shows a varying effect on the expression of FA-metabolizing enzyme in a variety of tissues." @default.
• W3128668892 created "2021-02-15" @default.
• W3128668892 creator A5000229520 @default.
• W3128668892 creator A5005785646 @default.
• W3128668892 creator A5022802322 @default.
• W3128668892 creator A5022882052 @default.
• W3128668892 creator A5026838518 @default.
• W3128668892 creator A5035979527 @default.
• W3128668892 creator A5041608565 @default.
• W3128668892 creator A5046259530 @default.
• W3128668892 creator A5082274293 @default.
• W3128668892 creator A5083599448 @default.
• W3128668892 date "2021-02-01" @default.
• W3128668892 modified "2023-10-09" @default.
• W3128668892 title "Effects of Simulated Weightlessness on Metabolizing Enzymes and Pharmacokinetics of Folic Acid in SD Rats" @default.
• W3128668892 cites W1891721997 @default.
• W3128668892 cites W1969474573 @default.
• W3128668892 cites W1978998408 @default.
• W3128668892 cites W1998725815 @default.
• W3128668892 cites W2052486505 @default.
• W3128668892 cites W2062266186 @default.
• W3128668892 cites W2112439068 @default.
• W3128668892 cites W2115974734 @default.
• W3128668892 cites W2128396525 @default.
• W3128668892 cites W2141721717 @default.
• W3128668892 cites W2160521610 @default.
• W3128668892 cites W2239425163 @default.
• W3128668892 cites W2520894026 @default.
• W3128668892 cites W2802762622 @default.
• W3128668892 cites W3018325832 @default.
• W3128668892 doi "https://doi.org/10.1248/bpb.b20-00299" @default.
• W3128668892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33518670" @default.
• W3128668892 hasPublicationYear "2021" @default.
• W3128668892 type Work @default.
• W3128668892 sameAs 3128668892 @default.
• W3128668892 citedByCount "3" @default.
• W3128668892 countsByYear W31286688922022 @default.
• W3128668892 crossrefType "journal-article" @default.
• W3128668892 hasAuthorship W3128668892A5000229520 @default.
• W3128668892 hasAuthorship W3128668892A5005785646 @default.
• W3128668892 hasAuthorship W3128668892A5022802322 @default.
• W3128668892 hasAuthorship W3128668892A5022882052 @default.
• W3128668892 hasAuthorship W3128668892A5026838518 @default.
• W3128668892 hasAuthorship W3128668892A5035979527 @default.
• W3128668892 hasAuthorship W3128668892A5041608565 @default.
• W3128668892 hasAuthorship W3128668892A5046259530 @default.
• W3128668892 hasAuthorship W3128668892A5082274293 @default.
• W3128668892 hasAuthorship W3128668892A5083599448 @default.
• W3128668892 hasBestOaLocation W31286688921 @default.
• W3128668892 hasConcept C104317684 @default.
• W3128668892 hasConcept C112705442 @default.
• W3128668892 hasConcept C134018914 @default.
• W3128668892 hasConcept C135763542 @default.
• W3128668892 hasConcept C16525657 @default.
• W3128668892 hasConcept C181199279 @default.
• W3128668892 hasConcept C181389837 @default.
• W3128668892 hasConcept C185592680 @default.
• W3128668892 hasConcept C22979827 @default.
• W3128668892 hasConcept C2777056448 @default.
• W3128668892 hasConcept C2780912031 @default.
• W3128668892 hasConcept C43563269 @default.
• W3128668892 hasConcept C515207424 @default.
• W3128668892 hasConcept C55493867 @default.
• W3128668892 hasConcept C80315684 @default.
• W3128668892 hasConcept C86803240 @default.
• W3128668892 hasConcept C98274493 @default.
• W3128668892 hasConceptScore W3128668892C104317684 @default.
• W3128668892 hasConceptScore W3128668892C112705442 @default.
• W3128668892 hasConceptScore W3128668892C134018914 @default.
• W3128668892 hasConceptScore W3128668892C135763542 @default.
• W3128668892 hasConceptScore W3128668892C16525657 @default.
• W3128668892 hasConceptScore W3128668892C181199279 @default.
• W3128668892 hasConceptScore W3128668892C181389837 @default.
• W3128668892 hasConceptScore W3128668892C185592680 @default.
• W3128668892 hasConceptScore W3128668892C22979827 @default.
• W3128668892 hasConceptScore W3128668892C2777056448 @default.
• W3128668892 hasConceptScore W3128668892C2780912031 @default.
• W3128668892 hasConceptScore W3128668892C43563269 @default.
• W3128668892 hasConceptScore W3128668892C515207424 @default.
• W3128668892 hasConceptScore W3128668892C55493867 @default.
• W3128668892 hasConceptScore W3128668892C80315684 @default.
• W3128668892 hasConceptScore W3128668892C86803240 @default.
• W3128668892 hasConceptScore W3128668892C98274493 @default.
• W3128668892 hasIssue "2" @default.
• W3128668892 hasLocation W31286688921 @default.
• W3128668892 hasOpenAccess W3128668892 @default.
• W3128668892 hasPrimaryLocation W31286688921 @default.
• W3128668892 hasRelatedWork W2028174972 @default.
• W3128668892 hasRelatedWork W2071624612 @default.
• W3128668892 hasRelatedWork W2089097166 @default.
• W3128668892 hasRelatedWork W2127981970 @default.
• W3128668892 hasRelatedWork W2145942125 @default.
• W3128668892 hasRelatedWork W2151915912 @default.
• W3128668892 hasRelatedWork W2376011676 @default.
• W3128668892 hasRelatedWork W2395595325 @default.
• W3128668892 hasRelatedWork W2739136678 @default.
• W3128668892 hasRelatedWork W3158161280 @default.
• W3128668892 hasVolume "44" @default.

• next