Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128671105> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W3128671105 abstract "Abstract Movement disorders are the heterogeneous group of disorders characterized by the progressive and selective impairment in motor function. Movement disorders like Huntington's disease (HD) and Tardive dyskinesia (TD) share many common features at both cellular and subcellular levels. Filgrastim is a recombinant methionyl granulocyte colony-stimulating factor (GCSF), shows neuroprotective properties in in-vivo models of movement disorders. The present study was designed to evaluate the neuroprotective effect of filgrastimin the animal models of haloperidol and 3-NP induced neurotoxicity in rats. Study was divided in two different protocol, in study one, rats were administered with haloperidol for 21 days, and filgrastim at the dose of (20, 40 & 60 µg/kg, s.c. ) was administered once a day, before haloperidol treatment and the following parameters (orofacial movements, rotarod, actophotometer) were assessed for TD. Similarly, in second study rats were administered with 3-NP for 21 days and filgrastimat the dose of (20 & 40 µg/kg, s.c. ) was administered, and following parameters (rotarod, narrow beam walk and open field test) were assessed for HD. In each study, on 22 nd day, animals were sacrificed, to isolate cortex and striatum for oxidative stress (LPO, GSH, SOD, catalase, and nitrate) parameters. The result revealed that haloperidol and 3-NP treatment significantly impaired motor coordination, oxidative defense and induce TD and HD like symptoms. Filgrastim pre-treatment significantly averted haloperidol & 3-NP induced behavioral and biochemical alterations, respectively. Conclusively, neuroprotective effect of filgrastim is credited to its antioxidant properties, hence filgrastim might be a novel therapeutic candidate to manage TD & HD." @default.
- W3128671105 created "2021-02-15" @default.
- W3128671105 creator A5006846992 @default.
- W3128671105 creator A5020718241 @default.
- W3128671105 creator A5059257864 @default.
- W3128671105 date "2021-02-09" @default.
- W3128671105 modified "2023-10-18" @default.
- W3128671105 title "Neuroprotective Effect of Filgrastim in Animal Models of 3-Nitropropionic Acid & Haloperidol Induced Neurotoxicity in Rats" @default.
- W3128671105 doi "https://doi.org/10.21203/rs.3.rs-158354/v1" @default.
- W3128671105 hasPublicationYear "2021" @default.
- W3128671105 type Work @default.
- W3128671105 sameAs 3128671105 @default.
- W3128671105 citedByCount "0" @default.
- W3128671105 crossrefType "posted-content" @default.
- W3128671105 hasAuthorship W3128671105A5006846992 @default.
- W3128671105 hasAuthorship W3128671105A5020718241 @default.
- W3128671105 hasAuthorship W3128671105A5059257864 @default.
- W3128671105 hasBestOaLocation W31286711051 @default.
- W3128671105 hasConcept C126322002 @default.
- W3128671105 hasConcept C185592680 @default.
- W3128671105 hasConcept C25498285 @default.
- W3128671105 hasConcept C2776151105 @default.
- W3128671105 hasConcept C2776694085 @default.
- W3128671105 hasConcept C2777767877 @default.
- W3128671105 hasConcept C2777981454 @default.
- W3128671105 hasConcept C2779171977 @default.
- W3128671105 hasConcept C2779491297 @default.
- W3128671105 hasConcept C2780062018 @default.
- W3128671105 hasConcept C2780948584 @default.
- W3128671105 hasConcept C29730261 @default.
- W3128671105 hasConcept C2985495968 @default.
- W3128671105 hasConcept C513476851 @default.
- W3128671105 hasConcept C71924100 @default.
- W3128671105 hasConcept C98274493 @default.
- W3128671105 hasConceptScore W3128671105C126322002 @default.
- W3128671105 hasConceptScore W3128671105C185592680 @default.
- W3128671105 hasConceptScore W3128671105C25498285 @default.
- W3128671105 hasConceptScore W3128671105C2776151105 @default.
- W3128671105 hasConceptScore W3128671105C2776694085 @default.
- W3128671105 hasConceptScore W3128671105C2777767877 @default.
- W3128671105 hasConceptScore W3128671105C2777981454 @default.
- W3128671105 hasConceptScore W3128671105C2779171977 @default.
- W3128671105 hasConceptScore W3128671105C2779491297 @default.
- W3128671105 hasConceptScore W3128671105C2780062018 @default.
- W3128671105 hasConceptScore W3128671105C2780948584 @default.
- W3128671105 hasConceptScore W3128671105C29730261 @default.
- W3128671105 hasConceptScore W3128671105C2985495968 @default.
- W3128671105 hasConceptScore W3128671105C513476851 @default.
- W3128671105 hasConceptScore W3128671105C71924100 @default.
- W3128671105 hasConceptScore W3128671105C98274493 @default.
- W3128671105 hasLocation W31286711051 @default.
- W3128671105 hasOpenAccess W3128671105 @default.
- W3128671105 hasPrimaryLocation W31286711051 @default.
- W3128671105 hasRelatedWork W1983878988 @default.
- W3128671105 hasRelatedWork W2061140793 @default.
- W3128671105 hasRelatedWork W2071070793 @default.
- W3128671105 hasRelatedWork W2593991421 @default.
- W3128671105 hasRelatedWork W2783447283 @default.
- W3128671105 hasRelatedWork W2791288087 @default.
- W3128671105 hasRelatedWork W2968526694 @default.
- W3128671105 hasRelatedWork W2972113715 @default.
- W3128671105 hasRelatedWork W4297019876 @default.
- W3128671105 hasRelatedWork W4313198889 @default.
- W3128671105 isParatext "false" @default.
- W3128671105 isRetracted "false" @default.
- W3128671105 magId "3128671105" @default.
- W3128671105 workType "article" @default.