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• W3128672188 abstract "With increase of social aging, Alzheimer's disease (AD) has been one of the serious diseases threatening human health. The occurrence of A β fibrils or plaques is recognized as the hallmark of AD. Currently, optical imaging has stood out to be a promising technique for the imaging of A β fibrils/plaques and the diagnosis of AD. However, restricted by their poor blood-brain barrier (BBB) penetrability, short-wavelength excitation and emission, and aggregation-caused quenching (ACQ) effect, the clinically used gold-standard optical probes such as thioflavin T (ThT) and thioflavin S (ThS), are not effective enough in the early diagnosis of AD in vivo . Herein, we put forward an “all-in-one” design principle and demonstrate its feasibility in developing high-performance fluorescent probes which are specific to A β fibrils/plaques and promising for super-early in - vivo diagnosis of AD. As a proof of concept, a simple rod-like amphiphilic NIR fluorescent AIEgen, i.e., AIE-CNPy-AD, is developed by taking the specificity, BBB penetration ability, deep-tissue penetration capacity, high signal-to-noise ratio (SNR) into consideration. AIE-CNPy-AD is constituted by connecting the electron-donating and accepting moieties through single bonds and tagging with a propanesulfonate tail, giving rise to the NIR fluorescence, aggregation-induced emission (AIE) effect, amphiphilicity, and rod-like structure, which in turn result in high binding-affinity and excellent specificity to A β fibrils/plaques, satisfactory ability to penetrate BBB and deep tissues, ultrahigh SNR and sensitivity, and high-fidelity imaging capability. In-vitro, ex-vivo, and in-vivo identifying of A β fibrils/plaques in different strains of mice indicate that AIE-CNPy-AD holds the universality to the detection of A β fibrils/plaques. It is noteworthy that AIE-CNPy-AD is even able to trace the small and sparsely distributed A β fibrils/plaques in very young AD model mice such as 4-month-old APP/PS1 mice which are reported to be the youngest mice to have A β deposits in brains, suggesting its great potential in diagnosis and intervention of AD at a super-early stage." @default.
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• W3128672188 date "2021-02-08" @default.
• W3128672188 modified "2023-09-26" @default.
• W3128672188 title "Rationally Designing Simple Rod-Like Amphiphilic NIR-Emissive AIE Probes for Precise In-Vivo Detection of Aβ Fibrils/Plaques at A Super-Early Stage" @default.
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• W3128672188 doi "https://doi.org/10.26434/chemrxiv.13699222.v1" @default.
• W3128672188 hasPublicationYear "2021" @default.
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