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- W3128685261 abstract "Aim:Enterococcus faecalis is a leading nosocomial pathogen in biofilm-associated polymicrobial infections. The study aims to understand pathogenicity and biofilm determinants of the pathogen by genome analysis. Methodology: Genome sequencing of a strong biofilm forming clinical isolate Enterococcus faecalis SK460 devoid of Fsr quorum-signaling system, was performed and comparative genomics was carried out among a set of pathogenic biofilm formers and nonpathogenic weak biofilm formers. Results: Analysis revealed a pool of virulence and adhesion related factors associated with pathogenicity. Absence of CRISPR-Cas system facilitated acquisition of pheromone responsive plasmid, pathogenicity island and phages. Comprehensive analysis identified a subset of accessory genes encoding polysaccharide lyase, sugar phosphotransferase system, phage proteins and transcriptional regulators exclusively in pathogenic biofilm formers. Conclusion: The study identified a set of genes specific to pathogenic biofilm formers and these can act as targets which in turn help to develop future treatment endeavors against enterococcal infections." @default.
- W3128685261 created "2021-02-15" @default.
- W3128685261 creator A5053638286 @default.
- W3128685261 creator A5066927195 @default.
- W3128685261 creator A5080253128 @default.
- W3128685261 date "2021-02-01" @default.
- W3128685261 modified "2023-09-27" @default.
- W3128685261 title "Comprehensive genomics depict accessory genes encoding pathogenicity and biofilm determinants in <i>Enterococcus faecalis</i>" @default.
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- W3128685261 doi "https://doi.org/10.2217/fmb-2020-0111" @default.
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