FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128697892> ?p ?o ?g. }

• W3128697892 endingPage "383" @default.
• W3128697892 startingPage "377" @default.
• W3128697892 abstract "A classical drug repurposing approach was applied to find new putative GPR40 allosteric binders. A two-step computational protocol was set up, based on an initial pharmacophoric-based virtual screening of the DrugBank database of known drugs, followed by docking simulations to confirm the interactions between the prioritised compounds and GPR40. The best-ranked entries showed binding poses comparable to that of TAK-875, a known allosteric agonist of GPR40. Three of them (tazarotenic acid, bezafibrate, and efaproxiral) affect insulin secretion in pancreatic INS-1 832/13 β-cells with EC50 in the nanomolar concentration (5.73, 14.2, and 13.5 nM, respectively). Given the involvement of GPR40 in type 2 diabetes, the new GPR40 modulators represent a promising tool for therapeutic intervention towards this disease. The ability to affect GPR40 was further assessed in human breast cancer MCF-7 cells in which this receptor positively regulates growth activities (EC50 values were 5.6, 21, and 14 nM, respectively)." @default.
• W3128697892 created "2021-02-15" @default.
• W3128697892 creator A5003329578 @default.
• W3128697892 creator A5015532308 @default.
• W3128697892 creator A5032250855 @default.
• W3128697892 creator A5033725334 @default.
• W3128697892 date "2021-01-01" @default.
• W3128697892 modified "2023-10-09" @default.
• W3128697892 title "Pharmacophore-guided repurposing of fibrates and retinoids as GPR40 allosteric ligands with activity on insulin release" @default.
• W3128697892 cites W1882183426 @default.
• W3128697892 cites W1964543779 @default.
• W3128697892 cites W1965607248 @default.
• W3128697892 cites W1974405795 @default.
• W3128697892 cites W1980672217 @default.
• W3128697892 cites W1982918806 @default.
• W3128697892 cites W2004811381 @default.
• W3128697892 cites W2038943432 @default.
• W3128697892 cites W2042311529 @default.
• W3128697892 cites W2054951377 @default.
• W3128697892 cites W2058316012 @default.
• W3128697892 cites W2073474683 @default.
• W3128697892 cites W2094784615 @default.
• W3128697892 cites W2118372040 @default.
• W3128697892 cites W2141109057 @default.
• W3128697892 cites W2397497372 @default.
• W3128697892 cites W2429754450 @default.
• W3128697892 cites W2532977935 @default.
• W3128697892 cites W2606563128 @default.
• W3128697892 cites W2738817021 @default.
• W3128697892 cites W2766733934 @default.
• W3128697892 cites W2767891136 @default.
• W3128697892 cites W2783293389 @default.
• W3128697892 cites W2885854889 @default.
• W3128697892 cites W2887608949 @default.
• W3128697892 cites W2941181729 @default.
• W3128697892 cites W2946148996 @default.
• W3128697892 cites W2955575197 @default.
• W3128697892 cites W2959798450 @default.
• W3128697892 cites W2967327218 @default.
• W3128697892 cites W3151193699 @default.
• W3128697892 doi "https://doi.org/10.1080/14756366.2020.1864629" @default.
• W3128697892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33525941" @default.
• W3128697892 hasPublicationYear "2021" @default.
• W3128697892 type Work @default.
• W3128697892 sameAs 3128697892 @default.
• W3128697892 citedByCount "4" @default.
• W3128697892 countsByYear W31286978922021 @default.
• W3128697892 countsByYear W31286978922022 @default.
• W3128697892 countsByYear W31286978922023 @default.
• W3128697892 crossrefType "journal-article" @default.
• W3128697892 hasAuthorship W3128697892A5003329578 @default.
• W3128697892 hasAuthorship W3128697892A5015532308 @default.
• W3128697892 hasAuthorship W3128697892A5032250855 @default.
• W3128697892 hasAuthorship W3128697892A5033725334 @default.
• W3128697892 hasBestOaLocation W31286978921 @default.
• W3128697892 hasConcept C103697762 @default.
• W3128697892 hasConcept C155261790 @default.
• W3128697892 hasConcept C166342909 @default.
• W3128697892 hasConcept C170493617 @default.
• W3128697892 hasConcept C185592680 @default.
• W3128697892 hasConcept C18903297 @default.
• W3128697892 hasConcept C2776038425 @default.
• W3128697892 hasConcept C2778938600 @default.
• W3128697892 hasConcept C2780035454 @default.
• W3128697892 hasConcept C32670627 @default.
• W3128697892 hasConcept C519536355 @default.
• W3128697892 hasConcept C55493867 @default.
• W3128697892 hasConcept C56173144 @default.
• W3128697892 hasConcept C71924100 @default.
• W3128697892 hasConcept C86803240 @default.
• W3128697892 hasConcept C98274493 @default.
• W3128697892 hasConceptScore W3128697892C103697762 @default.
• W3128697892 hasConceptScore W3128697892C155261790 @default.
• W3128697892 hasConceptScore W3128697892C166342909 @default.
• W3128697892 hasConceptScore W3128697892C170493617 @default.
• W3128697892 hasConceptScore W3128697892C185592680 @default.
• W3128697892 hasConceptScore W3128697892C18903297 @default.
• W3128697892 hasConceptScore W3128697892C2776038425 @default.
• W3128697892 hasConceptScore W3128697892C2778938600 @default.
• W3128697892 hasConceptScore W3128697892C2780035454 @default.
• W3128697892 hasConceptScore W3128697892C32670627 @default.
• W3128697892 hasConceptScore W3128697892C519536355 @default.
• W3128697892 hasConceptScore W3128697892C55493867 @default.
• W3128697892 hasConceptScore W3128697892C56173144 @default.
• W3128697892 hasConceptScore W3128697892C71924100 @default.
• W3128697892 hasConceptScore W3128697892C86803240 @default.
• W3128697892 hasConceptScore W3128697892C98274493 @default.
• W3128697892 hasFunder F4320313975 @default.
• W3128697892 hasFunder F4320321873 @default.
• W3128697892 hasFunder F4320324136 @default.
• W3128697892 hasIssue "1" @default.
• W3128697892 hasLocation W31286978921 @default.
• W3128697892 hasLocation W31286978922 @default.
• W3128697892 hasLocation W31286978923 @default.
• W3128697892 hasLocation W31286978924 @default.
• W3128697892 hasOpenAccess W3128697892 @default.
• W3128697892 hasPrimaryLocation W31286978921 @default.
• W3128697892 hasRelatedWork W1971248099 @default.

• next