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• W3128702967 abstract "To understand host–pathogen interactions and develop effective prevention and control strategies for human adenovirus (HAdV), it is essential to explore the characteristics of HAdV shedding. Hospitalized children <14 years who had severe HAdV pneumonia were tested for HAdV DNA by quantitative real-time PCR in nasopharyngeal aspirate (NPA). A total of 132 children were enrolled, including 102 patients with HAdV type 7 (HAdV-7) infection and 12 patients with HAdV type 3 (HAdV-3) infection. A total of 1372 qualified NPA samples were collected. There was a significant negative correlation between the viral load of HAdV and the course of the disease (Spearman r = −0.547, p = .000). HAdV-7 load decreased at a rate of 0.089 log10 copies/mL per day (95% CI: −0.096 to −0.081; R 2 = 0.332), and the duration of viral shedding was predicted to be 96.9 days (y = 8.624–0.089x). However, HAdV-3 load decreased more quickly (95% CI: – 0.229 to – 0.143; R 2 = 0.403), and the duration of viral shedding was 51.4 days (y = 9.558-0.186x). The median viral load of the HAdV-7 group at weeks 2 and 3, and more than 3 weeks postinfection was higher than that of the HAdV-3 group. No significant differences in the duration of viral shedding were found in different gender, age (>2 vs. ≤2 years), and with or without underlying diseases groups. Viral shedding in children with severe HAdV pneumonia persisted, among which HAdV-7 lasted longer than 3 months and the viral load decreased slowly than HAdV-3." @default.
• W3128702967 created "2021-02-15" @default.
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• W3128702967 date "2021-02-16" @default.
• W3128702967 modified "2023-10-09" @default.
• W3128702967 title "Persistent viral shedding of human adenovirus type 7 in children with severe pneumonia" @default.
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• W3128702967 doi "https://doi.org/10.1002/jmv.26864" @default.
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