Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128756870> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W3128756870 abstract "Host adaptive mutations in the influenza A virus (IAV) PB2 protein are critical for human infection, but their molecular action is not well understood. We observed that when IAV containing avian PB2 infects mammalian cells, vRNP aggregates that localize to the microtubule-organizing center (MTOC) are formed. These vRNP aggregates resemble LC3-associated autophagosome structures, with aggresome-like properties, in that they cause re-distribution of vimentin. However, electron microscopy revealed that these LC3-associated aggregates are not canonical double-membrane autophagosomes. Compared to mammalian-PB2 virus, avian-PB2 virus induces higher autophagic flux in infected cells, indicating an increased rate of autophagosomes containing avian vRNPs fusing with lysosomes. We found that p62 is essential for the formation of vRNP aggregates and that the Raptor-interacting region of p62 is required for interaction with vRNPs through the PB2 polymerase subunit. Selective autophagic sequestration during late stage virus replication is thus an additional strategy for host restriction of avian-PB2 IAV." @default.
- W3128756870 created "2021-02-15" @default.
- W3128756870 creator A5002465763 @default.
- W3128756870 creator A5003877491 @default.
- W3128756870 creator A5006713946 @default.
- W3128756870 creator A5007784434 @default.
- W3128756870 creator A5019585842 @default.
- W3128756870 creator A5019629770 @default.
- W3128756870 creator A5021166192 @default.
- W3128756870 creator A5033103064 @default.
- W3128756870 creator A5033288397 @default.
- W3128756870 creator A5043585511 @default.
- W3128756870 creator A5048732806 @default.
- W3128756870 creator A5052135528 @default.
- W3128756870 creator A5056304995 @default.
- W3128756870 creator A5056482982 @default.
- W3128756870 creator A5057642965 @default.
- W3128756870 creator A5058107383 @default.
- W3128756870 creator A5064509029 @default.
- W3128756870 date "2020-01-01" @default.
- W3128756870 modified "2023-10-16" @default.
- W3128756870 title "Mammalian Cells Utilize the Autophagy Process to Restrict Avian Influenza Virus Replication" @default.
- W3128756870 doi "https://doi.org/10.2139/ssrn.3758205" @default.
- W3128756870 hasPublicationYear "2020" @default.
- W3128756870 type Work @default.
- W3128756870 sameAs 3128756870 @default.
- W3128756870 citedByCount "0" @default.
- W3128756870 crossrefType "journal-article" @default.
- W3128756870 hasAuthorship W3128756870A5002465763 @default.
- W3128756870 hasAuthorship W3128756870A5003877491 @default.
- W3128756870 hasAuthorship W3128756870A5006713946 @default.
- W3128756870 hasAuthorship W3128756870A5007784434 @default.
- W3128756870 hasAuthorship W3128756870A5019585842 @default.
- W3128756870 hasAuthorship W3128756870A5019629770 @default.
- W3128756870 hasAuthorship W3128756870A5021166192 @default.
- W3128756870 hasAuthorship W3128756870A5033103064 @default.
- W3128756870 hasAuthorship W3128756870A5033288397 @default.
- W3128756870 hasAuthorship W3128756870A5043585511 @default.
- W3128756870 hasAuthorship W3128756870A5048732806 @default.
- W3128756870 hasAuthorship W3128756870A5052135528 @default.
- W3128756870 hasAuthorship W3128756870A5056304995 @default.
- W3128756870 hasAuthorship W3128756870A5056482982 @default.
- W3128756870 hasAuthorship W3128756870A5057642965 @default.
- W3128756870 hasAuthorship W3128756870A5058107383 @default.
- W3128756870 hasAuthorship W3128756870A5064509029 @default.
- W3128756870 hasConcept C104292427 @default.
- W3128756870 hasConcept C104317684 @default.
- W3128756870 hasConcept C140704245 @default.
- W3128756870 hasConcept C159047783 @default.
- W3128756870 hasConcept C185592680 @default.
- W3128756870 hasConcept C187436293 @default.
- W3128756870 hasConcept C190283241 @default.
- W3128756870 hasConcept C203522944 @default.
- W3128756870 hasConcept C2522874641 @default.
- W3128756870 hasConcept C2777546802 @default.
- W3128756870 hasConcept C519248777 @default.
- W3128756870 hasConcept C54355233 @default.
- W3128756870 hasConcept C60325843 @default.
- W3128756870 hasConcept C67705224 @default.
- W3128756870 hasConcept C75934600 @default.
- W3128756870 hasConcept C82381507 @default.
- W3128756870 hasConcept C86803240 @default.
- W3128756870 hasConcept C95444343 @default.
- W3128756870 hasConceptScore W3128756870C104292427 @default.
- W3128756870 hasConceptScore W3128756870C104317684 @default.
- W3128756870 hasConceptScore W3128756870C140704245 @default.
- W3128756870 hasConceptScore W3128756870C159047783 @default.
- W3128756870 hasConceptScore W3128756870C185592680 @default.
- W3128756870 hasConceptScore W3128756870C187436293 @default.
- W3128756870 hasConceptScore W3128756870C190283241 @default.
- W3128756870 hasConceptScore W3128756870C203522944 @default.
- W3128756870 hasConceptScore W3128756870C2522874641 @default.
- W3128756870 hasConceptScore W3128756870C2777546802 @default.
- W3128756870 hasConceptScore W3128756870C519248777 @default.
- W3128756870 hasConceptScore W3128756870C54355233 @default.
- W3128756870 hasConceptScore W3128756870C60325843 @default.
- W3128756870 hasConceptScore W3128756870C67705224 @default.
- W3128756870 hasConceptScore W3128756870C75934600 @default.
- W3128756870 hasConceptScore W3128756870C82381507 @default.
- W3128756870 hasConceptScore W3128756870C86803240 @default.
- W3128756870 hasConceptScore W3128756870C95444343 @default.
- W3128756870 hasLocation W31287568701 @default.
- W3128756870 hasOpenAccess W3128756870 @default.
- W3128756870 hasPrimaryLocation W31287568701 @default.
- W3128756870 hasRelatedWork W10781848 @default.
- W3128756870 hasRelatedWork W11513594 @default.
- W3128756870 hasRelatedWork W14874507 @default.
- W3128756870 hasRelatedWork W15834657 @default.
- W3128756870 hasRelatedWork W17727218 @default.
- W3128756870 hasRelatedWork W19082146 @default.
- W3128756870 hasRelatedWork W2708523 @default.
- W3128756870 hasRelatedWork W4946853 @default.
- W3128756870 hasRelatedWork W7956238 @default.
- W3128756870 hasRelatedWork W8128648 @default.
- W3128756870 isParatext "false" @default.
- W3128756870 isRetracted "false" @default.
- W3128756870 magId "3128756870" @default.
- W3128756870 workType "article" @default.