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• W3128776122 startingPage "1188" @default.
• W3128776122 abstract "Proprioception is essential for behavior and provides a sense of our body movements in physical space. Proprioceptor organs are thought to be only in the periphery. Whether the central nervous system can intrinsically sense its own movement remains unclear. Here we identify a segmental organ of proprioception in the adult zebrafish spinal cord, which is embedded by intraspinal mechanosensory neurons expressing Piezo2 channels. These cells are late-born, inhibitory, commissural neurons with unique molecular and physiological profiles reflecting a dual sensory and motor function. The central proprioceptive organ locally detects lateral body movements during locomotion and provides direct inhibitory feedback onto rhythm-generating interneurons responsible for the central motor program. This dynamically aligns central pattern generation with movement outcome for efficient locomotion. Our results demonstrate that a central proprioceptive organ monitors self-movement using hybrid neurons that merge sensory and motor entities into a unified network." @default.
• W3128776122 created "2021-02-15" @default.
• W3128776122 creator A5010688084 @default.
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• W3128776122 creator A5083433721 @default.
• W3128776122 creator A5088825287 @default.
• W3128776122 date "2021-04-01" @default.
• W3128776122 modified "2023-10-17" @default.
• W3128776122 title "A spinal organ of proprioception for integrated motor action feedback" @default.
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