Matches in SemOpenAlex for { <https://semopenalex.org/work/W3128784217> ?p ?o ?g. }
- W3128784217 endingPage "361" @default.
- W3128784217 startingPage "345" @default.
- W3128784217 abstract "Nutraceuticals’ properties render them a good source of potential drug leads in pharmaceutical research, but the elucidation of their mechanism of action (MoA) is challenging, partly because natural compounds can bind multiple targets with unrelated structures. In this work, we present a pipeline that integrates complementary systems biology and chemoinformatics-based approaches with the goal of identifying potential targets and generating MoA hypotheses that can be tested in a new cycle of experiments. We focus on how we can integrate knowledge from multiple sources into an ensemble score and translate our results into biological insights, providing use cases on three extensively studied nutraceuticals, epigallocatechin-3-gallate, quercetin, and resveratrol as well as on a prototypical proinflammatory stimulus, TNF-α. Fifty-seven of our top 60 predicted targets were already identified in the literature as experimentally perturbed by the corresponding compounds, interestingly observing anticancer, antiviral, and antibacterial MoA to be shared among the tested nutraceuticals." @default.
- W3128784217 created "2021-02-15" @default.
- W3128784217 creator A5007867427 @default.
- W3128784217 creator A5009882702 @default.
- W3128784217 creator A5012278670 @default.
- W3128784217 creator A5035249529 @default.
- W3128784217 creator A5070180629 @default.
- W3128784217 creator A5087038430 @default.
- W3128784217 date "2021-01-01" @default.
- W3128784217 modified "2023-10-18" @default.
- W3128784217 title "Systems pharmacology investigation of mechanism of action of nutraceuticals" @default.
- W3128784217 cites W1737556493 @default.
- W3128784217 cites W1814763565 @default.
- W3128784217 cites W1906381714 @default.
- W3128784217 cites W1963846930 @default.
- W3128784217 cites W1965694039 @default.
- W3128784217 cites W1968364537 @default.
- W3128784217 cites W1968643486 @default.
- W3128784217 cites W1971849220 @default.
- W3128784217 cites W1973905580 @default.
- W3128784217 cites W1975462549 @default.
- W3128784217 cites W1976029010 @default.
- W3128784217 cites W1977252276 @default.
- W3128784217 cites W1985173430 @default.
- W3128784217 cites W1987594745 @default.
- W3128784217 cites W1990000596 @default.
- W3128784217 cites W1992482172 @default.
- W3128784217 cites W1995008770 @default.
- W3128784217 cites W1997707189 @default.
- W3128784217 cites W2002449811 @default.
- W3128784217 cites W2006169733 @default.
- W3128784217 cites W2007712979 @default.
- W3128784217 cites W2015401980 @default.
- W3128784217 cites W2027327945 @default.
- W3128784217 cites W2029136400 @default.
- W3128784217 cites W2033588393 @default.
- W3128784217 cites W2035356097 @default.
- W3128784217 cites W2035617239 @default.
- W3128784217 cites W2040435660 @default.
- W3128784217 cites W2048872630 @default.
- W3128784217 cites W2056669249 @default.
- W3128784217 cites W2058539819 @default.
- W3128784217 cites W2058629519 @default.
- W3128784217 cites W2061668669 @default.
- W3128784217 cites W2061880858 @default.
- W3128784217 cites W2062911417 @default.
- W3128784217 cites W2066365279 @default.
- W3128784217 cites W2068862545 @default.
- W3128784217 cites W2075938797 @default.
- W3128784217 cites W2081525633 @default.
- W3128784217 cites W2084358328 @default.
- W3128784217 cites W2085895306 @default.
- W3128784217 cites W2086505785 @default.
- W3128784217 cites W2090745377 @default.
- W3128784217 cites W2092961827 @default.
- W3128784217 cites W2095013915 @default.
- W3128784217 cites W2098119255 @default.
- W3128784217 cites W2099660028 @default.
- W3128784217 cites W2099870643 @default.
- W3128784217 cites W2104752607 @default.
- W3128784217 cites W2106248983 @default.
- W3128784217 cites W2106251882 @default.
- W3128784217 cites W2111344601 @default.
- W3128784217 cites W2117660667 @default.
- W3128784217 cites W2121604817 @default.
- W3128784217 cites W2122759376 @default.
- W3128784217 cites W2125033229 @default.
- W3128784217 cites W2125552828 @default.
- W3128784217 cites W2126952890 @default.
- W3128784217 cites W2129079547 @default.
- W3128784217 cites W2140573009 @default.
- W3128784217 cites W2146264532 @default.
- W3128784217 cites W2146727863 @default.
- W3128784217 cites W2148073828 @default.
- W3128784217 cites W2159675211 @default.
- W3128784217 cites W2163856183 @default.
- W3128784217 cites W2164513602 @default.
- W3128784217 cites W2165037318 @default.
- W3128784217 cites W2168938595 @default.
- W3128784217 cites W2248154415 @default.
- W3128784217 cites W2259739165 @default.
- W3128784217 cites W2277194059 @default.
- W3128784217 cites W2277406115 @default.
- W3128784217 cites W2294516783 @default.
- W3128784217 cites W2297606889 @default.
- W3128784217 cites W2327127510 @default.
- W3128784217 cites W2514313270 @default.
- W3128784217 cites W2552681633 @default.
- W3128784217 cites W2557833574 @default.
- W3128784217 cites W2558999090 @default.
- W3128784217 cites W2559588208 @default.
- W3128784217 cites W2568166803 @default.
- W3128784217 cites W2608586744 @default.
- W3128784217 cites W2612253630 @default.
- W3128784217 cites W2612467560 @default.
- W3128784217 cites W2743187300 @default.
- W3128784217 cites W2754253179 @default.
- W3128784217 cites W2756041018 @default.