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- W3128791230 abstract "From the functional standpoint, broadly, three kinds of functional DNA sequences exist: one that encodes proteins, second that encodes only RNA (noncoding DNA), and third that does not transcribe at all (Noncoding DNA) historically people have paid attention to the protein-coding genes. For the last two-and-a-half decades, the noncoding RNA has taken center stage. However, the role of noncoding DNA (the dark matter of genome) is still largely unknown. We asked a simple question: How did nature decide to allocate protein-coding and RNA-coding jobs to a specific set of sequences? Did she sample all possibilities in the neighborhood of protein-coding genes, retaining good results (protein- and RNA-encoding genes), retiring not-so-relevant results (pseudogenes), and leaving some genome sequences untouched (nonexpressive genome) To answer these, we expressed some noncoding intergenic sequences from Escherichia coli into functional proteins. The success of this pilot experiment led us toward building a knowledge base that predicts the outcome of making user-defined genes from nonexpressive DNA sequences. In this chapter, the idea of lab-made genes shall be presented from the original concept to its present state where novel therapeutic molecules against cancer, infectious diseases, and neurodegenerative diseases have been found. We call this new platform “FLAGSHIP”—a novel drug discovery platform originating from the dark matter of the genome." @default.
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- W3128791230 date "2021-01-01" @default.
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- W3128791230 title "FLAGSHIP: A novel drug discovery platform originating from the “dark matter of the genome”" @default.
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- W3128791230 doi "https://doi.org/10.1016/b978-0-12-821972-0.00011-3" @default.
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