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- W3128798771 abstract "Abstract Memory consolidation requires astrocytic microdomains for protein recycling; but whether this lays a mechanistic foundation for long-term information storage remains enigmatic. Here we demonstrate that persistent synaptic strengthening invited astrocytic microdomains to convert initially internalized (pro)-brain-derived neurotrophic factor (proBDNF) into active prodomain (BDNFpro) and mature BDNF (mBDNF) for synaptic re-use. While mBDNF activates TrkB, we uncovered a previously unsuspected function for the cleaved BDNFpro, which increases TrkB/SorCS2 receptor complex at post-synaptic sites. Astrocytic BDNFpro release reinforced TrkB phosphorylation to sustain long-term synaptic potentiation and to retain memory in the novel object recognition behavioral test. Thus, the switch from one inactive state to a multi-functional one of the proBDNF provides post-synaptic changes that survive the initial activation (molecular memory). This molecular asset confines local information storage in astrocytic microdomains to selectively support memory circuits." @default.
- W3128798771 created "2021-02-15" @default.
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- W3128798771 date "2021-01-28" @default.
- W3128798771 modified "2023-10-18" @default.
- W3128798771 title "Astrocytic Microdomains Confine A “molecular Memory” Enabling Long-Term Information Storage for Memory Consolidation" @default.
- W3128798771 doi "https://doi.org/10.21203/rs.3.rs-139639/v1" @default.
- W3128798771 hasPublicationYear "2021" @default.
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