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• W3128851330 abstract "ABSTRACTIn eukaryotes, genomic DNA is packaged into nucleosomes, which are the basal components coordinating both the structures and functions of chromatin. In this study, we screened a collection of mutations for histone H3/H4 mutants in Saccharomyces cerevisiae that affect the DNA damage sensitivity of DNA damage tolerance (DDT)-deficient cells. We identified a class of histone H3/H4 mutations that suppress methyl methanesulfonate (MMS) sensitivity of DDT-deficient cells (referred to here as the histone SDD mutations), which likely cluster on a specific H3-H4 interface of the nucleosomes. The histone SDD mutations did not suppress the MMS sensitivity of DDT-deficient cells in the absence of Rad51, indicating that homologous recombination (HR) is responsible for DNA damage resistance. Furthermore, the histone SDD mutants showed reduced levels of PCNA ubiquitination after exposure to MMS or UV irradiation, consistent with decreased MMS-induced mutagenesis relative to that of wild-type cells. We also found that histone SDD mutants lacking the INO80 chromatin remodeler impair HR-dependent recovery from MMS-induced replication arrest, resulting in defective S-phase progression and increased Rad52 foci. Taken together, our data provide novel insights into nucleosome functions, which link INO80-dependent chromatin remodeling to the regulation of DDT and HR during the recovery from replication blockage.KEYWORDS: DNA damage toleranceINO80budding yeasthistoneshomologous recombination SUPPLEMENTAL MATERIALSupplemental material is available online only. ACKNOWLEDGMENTSWe thank Tomomi Ohtawara for technical assistance and members of the Hishida laboratory for helpful discussions.This work was supported by JSPS KAKENHI grant numbers JP17K07290 and JP23114007 (to T.H.) and JP20K05790 (to G.A.)." @default.
• W3128851330 created "2021-02-15" @default.
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• W3128851330 date "2021-04-01" @default.
• W3128851330 modified "2023-10-09" @default.
• W3128851330 title "A Conserved Histone H3-H4 Interface Regulates DNA Damage Tolerance and Homologous Recombination during the Recovery from Replication Stress" @default.
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• W3128851330 doi "https://doi.org/10.1128/mcb.00044-20" @default.
• W3128851330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8088132" @default.
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• W3128851330 hasPublicationYear "2021" @default.
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